Users Online: 1790 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  
Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 


RSACP wishes to inform that it shall be discontinuing the dispatch of print copy of JOACP to it's Life members. The print copy of JOACP will be posted only to those life members who send us a written confirmation for continuation of print copy.
Kindly email your affirmation for print copies to dranjugrewal@gmail.com preferably by 30th June 2019.

 
RESEARCH PAPER
Year : 2010  |  Volume : 26  |  Issue : 4  |  Page : 480-483

A comparative study between palonosetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy


1 Associate Professor, Department of Anaesthesiology, Calcutta National Medical College, Kolkata, India
2 Assistant Professor, Department of Anaesthesiology, Calcutta National Medical College, Kolkata, India
3 Second Year M.D. PGT, Department of Anaesthesiology, Calcutta National Medical College, Kolkata, India
4 Professor and Head, Department of Anaesthesiology, Calcutta National Medical College, Kolkata, India

Correspondence Address:
Dhurjoti Prosad Bhattacharjee
Associate Professor, Department of Anaesthesiology, Calcutta National Medical College, Kolkata
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 21547174

Rights and PermissionsRights and Permissions

Background: Postoperative nausea and vomiting (PONV) is commonly seen after laparoscopic surgery. In this randomized double blind prospective clinical study, we investigated and compared the efficacy of palonosetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy. Patients & Methods: Sixty female patients (18-65 yrs of age) undergoing elective laparoscopic cholecystectomy were randomly allocated one of the two groups containing 30 patients each. Group P received palonosetron 75 μg intravenously as a bolus before induction of anaesthesia. Group G received granisetron 2.5 mg intravenously as a bolus before induction. Results: The incidence of a complete response (no PONV, no rescue medication) during 0-3 hour in the postoperative period was 86.6% with granisetron and 90% with palonosetron, the incidence during 3-24 hour postoperatively was 83.3% with granisetron and 90% with palonosetron. During 24-48 hour, the incidence was 66.6% and 90% respectively (p<0.05). The incidence of adverse effects were statistically insignificant between the groups. Conclusion: Prophylactic therapy with palonosetron is more effective than granisetron for long term prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3404    
    Printed138    
    Emailed5    
    PDF Downloaded892    
    Comments [Add]    

Recommend this journal