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Table of Contents
LETTER TO THE EDITOR
Year : 2012  |  Volume : 28  |  Issue : 1  |  Page : 134-135

Fospropofol: Pharmacokinetics?


1 Department of Pharmacology, DMCH, Ludhiana, Punjab, India
2 Department of Medicine, DMCH, Ludhiana, Punjab, India

Date of Web Publication31-Jan-2012

Correspondence Address:
Bharti Mahajan
Department of Pharmacology, DMCH, Ludhiana, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9185.92472

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How to cite this article:
Mahajan B, Kaushal S, Mahajan R. Fospropofol: Pharmacokinetics?. J Anaesthesiol Clin Pharmacol 2012;28:134-5

How to cite this URL:
Mahajan B, Kaushal S, Mahajan R. Fospropofol: Pharmacokinetics?. J Anaesthesiol Clin Pharmacol [serial online] 2012 [cited 2020 Jul 7];28:134-5. Available from: http://www.joacp.org/text.asp?2012/28/1/134/92472

Sir,

We read the article "Fospropofol: Clinical Pharmacology" with great interest. [1] However, we would like to point out that there has been the discussion on pharmacokinetic (P/K) and pharmacodynamic (P/D) properties of fospropofol, [2] which led to the retraction of six studies due to possible errors in propofol assays. [3] This analytical inaccuracy in propofol assay was discovered by the investigators after publication of the data regarding the pharmacokinetic and pharmacodynamic properties of fospropofol and its tolerability. [3]

These studies in phase I or phase II were conducted by MGI Pharma in two independent academic facilities in Europe (Gent, Belgium and Erlangen, Germany). After the detection of the error, MGI Pharma stated that further studies will be conducted within a period of 12 months, and the degree of error will be estimated from the previously published studies. [3] However, the ownership of the drug was transferred from MGI Pharma to Eisai (Woodcliff Lake, NJ). MGI Pharma hence requested the studies to be retracted, as the investigators were unable to conduct new studies within the mentioned time period of 12 months. [4]

The published pharmacokinetic data on fospropofol were derived using an analytical method that has now been shown to be inaccurate; correct pharmacokinetic data are not yet available. [5]

 
  References Top

1.Bengalorkar GM, Bhuvana K, Sarala N, Kumar TN. Fospropofol: Clinical Pharmacology. J Anaesthesiol Clin Pharmacol 2011;27:79-83.   Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Shah A, Mistry B, Gibiansky E, Gibiansky L. Fospropofol assay issues and impact on pharmacokinetic and pharmacodynamic evaluation. Anesth Analg 2009;108:382.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.Struys MM, Fechner J, Schuttler J, Schwilden H. Erroneously published fospropofol pharmacokinetic-pharmacodynamic data and retraction of the affected publications. Anesthesiology 2010;112:1056-7.  Back to cited text no. 3
    
4.Pergolizzi JV, Gan TJ, Plavin S, Labhsetwar S, Taylor R. Perspectives on the Role of Fospropofol in the Monitored Anesthesia Care Setting. Anesthesiol Res Pract 2011;2011:458920.   Back to cited text no. 4
    
5.Patel PM, Patel HH, Roth DM. General anesthetics and therapeutic gases. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman and Gilmans: The pharmacological basis of therapeutics. 12 th ed. New York: McGraw-Hill Medical Publishing Division; 2011. p. 527-64.  Back to cited text no. 5
    



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