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ORIGINAL ARTICLE
Year : 2012  |  Volume : 28  |  Issue : 4  |  Page : 456-459

A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy


1 Department of Anaesthesiology, Burdwan Medical College, Burdwan, West Bengal, India
2 Department of Anaesthesiology, Calcutta National Medical College, Kolkata, West Bengal, India

Correspondence Address:
Mausumi Neogi
41, Hrishi Bankim Street, Konnagar, Hoogly, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9185.101903

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Background: Carbon dioxide pneumoperitoneum for laparoscopic surgery increases arterial pressures, heart rate, and systemic vascular resistance. In this randomized double-blind placebo-controlled clinical study, we investigated the efficacy of gabapentin premedication to provide perioperative hemodynamic stability in patients undergoing laparoscopic cholecystectomy. Materials and Methods: Sixty patients, of either sex (18-65 years of age) undergoing elective laparoscopic cholecystectomy were randomly allocated to two groups of 30 patients each. Patients of group G received oral gabapentin 900 mg 2 h before induction of anesthesia, while patients in group P received placebo at the same time. Results: Mean arterial pressure in patients of group G were significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, as compared to group P, throughout the pneumoperitoneum. Similarly, heart rate in group G was significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, in comparison to group P, throughout the peumoperitoneum. Intravenous labetalol was required, to control intraoperative hypertension, in 33.3% (10 out of 30) patients in group P. There was no significant difference in the incidence of adverse effects between the two groups. Conclusion: Gabapentin premedication provided perioperative hemodynamic stability during laparoscopic surgery.


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