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Table of Contents
REVIEW ARTICLE
Year : 2014  |  Volume : 30  |  Issue : 1  |  Page : 10-18

Spinal anesthesia in children: A review


1 Department of Anesthesiology and Intensive Care, Delhi State Cancer Hospital, Dilshad Garden, New Delhi, India
2 LHMC and Associated Hospitals, New Delhi, India

Date of Web Publication24-Jan-2014

Correspondence Address:
Anju Gupta
438, Pocket A, Sarita Vihar, New Delhi - 110 076
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9185.125687

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  Abstract 

Even after a vast safety record, the role of spinal anesthesia (SA) as a primary anesthetic technique in children remains contentious and is mainly limited to specialized pediatric centers. It is usually practiced on moribund former preterm infants (<60 weeks post-conception) to reduce the incidence of post-operative apnea when compared to general anesthesia (GA). However, there is ample literature to suggest its safety and efficacy for suitable procedures in older children as well. SA in children has many advantages as in adults with an added advantage of minimal cardio-respiratory disturbance. Recently, several reports from animal studies have raised serious concerns regarding the harmful effects of GA on young developing brain. This may further increase the utility of SA in children as it provides all components of balanced anesthesia technique. Also, SA can be an economical option for countries with finite resources. Limited duration of surgical anesthesia in children is one of the major deterrents for its widespread use in them. To overcome this, several additives like epinephrine, clonidine, fentanyl, morphine, neostigmine etc. have been used and found to be effective even in neonates. But, the developing spinal cord may also be vulnerable to drug-related toxicity, though this has not been systematically evaluated in children. So, adjuvants and drugs with widest therapeutic index should be preferred in children. Despite its widespread use, incidence of side-effects is low and permanent neurological sequalae have not been reported with SA. Literature yields encouraging results regarding its safety and efficacy. Technical skills and constant vigilance of experienced anesthesia providers is indispensable to achieve good results with this technique.

Keywords: Additives, children, complications, pediatric, regional anesthesia, spinal, spinal anesthesia


How to cite this article:
Gupta A, Usha U. Spinal anesthesia in children: A review. J Anaesthesiol Clin Pharmacol 2014;30:10-8

How to cite this URL:
Gupta A, Usha U. Spinal anesthesia in children: A review. J Anaesthesiol Clin Pharmacol [serial online] 2014 [cited 2017 Sep 20];30:10-8. Available from: http://www.joacp.org/text.asp?2014/30/1/10/125687


  Introduction Top


August Bier, in 1898, first reported the successful use of SA in an 11-year-old child for surgery of thigh tumor. [1] Following this, Bainbridge [2] (1901), Tyrell Gray [3] (1909), Berkowitz and Greene [4] (1950) described SA as an excellent alternative to general anesthesia (GA) in children including thoracic surgeries (lobectomy, pneumonectomy). [5] However, by middle of the century, considerable improvement in techniques of GA (introduction of muscle relaxants and safe intravenous induction agents) along with lack of expertise for SA (fear of adverse effects, lack of patient co-operation) possibly prevented widespread use of SA in children.

In 1970's, an awareness that children feel pain led to a renewed interest in pediatric regional anesthesia (RA) with the realization that RA can be complimentary to GA. But, SA did not gain popularity until 1984, when it was reintroduced as an alternative to GA in the high-risk former preterm neonates, as a means of limiting the incidence of post-operative apnea and bradycardia, by Chris Abajian of Vermont University. [6] Since then, SA has become a proven standard of care for moribund neonates. [7],[8],[9],[10] The Vermont spinal registry proved its safety in 1554 infants including the ex-premature and advocated its use in all infants undergoing lower abdominal or extremity surgery. [10] Its efficacy and safety is also established in older children as an alternative to GA. [11],[12],[13],[14]

Several experimental studies in animals have raised concerns regarding susceptibility of developing brain to some anesthetic agents leading to functional and neurobehavioral deficits. [15] The fact that anesthetic agents can cause human brain cell injury is still not proven. But, such issues may incline pediatric anesthesiologists to choose regional techniques whenever possible, especially in such age groups where rapid brain development is occurring. In this article, we aim to review the practice of SA in children with a special focus on limitations precluding its routine use and to find out the possible solutions to counter them. The keywords "pediatric spinal anesthesia" in PUBMED revealed a total of 863 titles and 106 review articles published after 1990. The relevant articles along with their references were searched and extensively studied.

Anatomical and physiological differences between adults and neonates

  1. Dural Sac: Terminates at S 3 and spinal cord at L 3 vertebral levels, at birth. Adult level (S 2 and L 1 respectively) is not reached until 2 nd year of life [Figure 1]. Thus, it is prudent to use a low approach (L 4 - 5 or L 5 -S 1 ) to avoid damage to spinal cord [16] [Figure 2] and [Figure 3]. Intercristal line (Tuffier's line) still remains a reliable landmark similar to adults since in younger children, it passes through L 4-5 /L 5 -S 1 . Newborns have a narrow subarachnoid space (6-8 mm) and low CSF pressure, necessitating greater precision and avoidance of lateral deviation.
  2. CSF: Children require higher dose of local anesthetic (LA) drug due to higher total CSF (neonates 10 ml/kg, infants and toddlers 4 ml/kg, adults 2 ml/kg) and spinal CSF volumes (50% in children vs. 33% in adults). [17],[18]
  3. Meninges: Highly vascular piamater and high cardiac output lead to rapid re-absorption of LA and shorter duration of block in children, explaining 30% prolongation of block by addition of epinephrine, unlike in adults. [6]
  4. Myelination: In children, endoneurium is loose, presenting little barrier to drug diffusion, with faster onset and offset of block. [16]
  5. Spine and Ligaments: Ligaments are less densely packed, and feel of loss of resistance is less marked. Increased spine flexibility limits normal thoracic kyphosis and facilitates cephalad spread and higher level of sensory block. [19] Laminae are cartilaginous; hence, paramedian approach should be avoided.
  6. CVS: Hemodynamic suppression following SA is absent in children due to a smaller peripheral blood pool, immature sympathetic autonomic system, and compensatory reduction in vagal efferent activity. [19] Hence, preloading before SA is not a routine in children.
  7. Respiratory system: High levels (T 2-4 ) of block reduce outward motion of lower ribcage, decrease intercostal muscle activity and may lead to paradoxical respiratory movement in children. However, diaphragm compensates for loss of ribcage contribution in most cases. [20]
Figure 1: Anatomical differences between pediatric and adult spinal cord

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Figure 2: Anatomical landmarks for pediatric spinal

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Figure 3: Surface markings for SA in an infant

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Subarachnoid block in children

Some of the applications of SA in children and large published series on use of SA in children are being summarized in [Table 1] and [Table 2]. The contraindication of spinal block in children is similar to those in adults.
Table 1: Documented applications of SA in children

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Table 2: Summary of a few published series on SA in children

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Spinal needles, drugs, and dosage

Various types of spinal needles have been described depending upon the length, gauge, tip design (cutting/ pencil point), bevel (long/short), and presence /absence of stylet. The length of spinal needle varies from 25-50 mm (25-30 mm for infants, 50 mm for small children). [17] Both cutting and pencil point needles have been used with similar success. [35],[36] A 90 mm adult spinal needle has also been used in children. [12],[22],[36],[37] A shorter pediatric needle allows more precision in movement, will bend rather than break in case of movement, and has a smaller dead space. A short bevel allows better appreciation of tissue resistance and reduces the chance of incomplete injection of drug. IV catheter's hollow stylet and hypodermic needles have also been used, but they carry a risk of formation of epidermoid tumor from deposition of skin tag. [38] Kokki et al. compared 25G and 29G Quincke spinal needles in children and concluded that puncture characteristics favored 25G. [37] Use of 1 ml tuberculin syringe allows greater precision in drug delivery.

Local Anesthetic (LA) solutions and additives - Isobaric and hyperbaric Bupivacaine or Tetracaine (0.5%) remain the most popular agents for pediatric SA. Newer drugs like Ropivacaine and L-bupivacaine are also safe and effective. Ropivacaine 0.5% was used in children (1-17 years) at a dose of 0.5 mg/kg with good success. [39] Duration of motor block is significantly shorter than equipotent doses of other drugs. [39] Levobupivacaine has a clinical profile similar to bupivacaine and has been used in similar doses. Kokki et al. successfully used 0.5% levobupivacaine in doses of 0.3 mg/kg in children (1-14 years). [40] Frawley et al. found 1 mg/kg of isobaric solutions of 0.5% bupivacaine and ropivacaine and 1.02 mg/kg of L-bupivacaine to be equipotent in infants. [41] But, such high doses should be used with caution because of risk of neurotoxicity. Dosage of LA agents varies inversely with the body weight as shown in [Table 3]. Lignocaine has gone out of vogue because of its shorter duration of action and reports of neurological complications in adults. Baricity of LA drug is not as important because both isobaric and hyperbaric solutions have similar block characteristics in children. [42]
Table 3: Recommended doses and approximate duration of LA for SA in infants and children

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Since short duration of action of SA is a major limitation in children, a variety of additives like adrenaline, morphine, fentanyl, neostigmine, clonidine have been tried to prolong the block [Table 4]. Addition of epinephrine to LA reduces the total dose, increases the safety margin, and prolongs the duration (up to 30%), but its use has been questioned because of fear of cord ischemia. [55] Dexmedetomidine, a new α2 agonist, has been used as an additive via epidural route in children, but not intrathecally. Though various LA and additives used for SA have been reported to be relatively safe, but the potential spinal cord toxicity with the drugs delivered intrathecally during early phases of development cannot be precluded. Moreover, younger children (infants and neonates) may not be able to report sensory symptoms, and subtle changes may be missed. So, drugs with well documented safety profile with a wide therapeutic index should be used. [56]
Table 4: Additives used for spinal anesthesia in children

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Pre-operative preparation and premedication

Children are apprehensive from the thought of parental separation, pain of surgery, and use of needles. It is very important to discuss clearly the advantages of SA over GA with parents and older children. [16] They should be explained about the technique in detail. An informed consent should be obtained from the parents and assent directly from older children. [35]

EMLA cream should be applied to lumbar puncture area and IV cannulation site 1 hour prior to arrival in OR (not licensed for preterm <37 weeks). [57] Good dermal analgesia (local infiltration with 1% lignocaine) may avoid the need for sedation in some children. Sedation is generally avoided in preterm and former preterm infants because of risk of apnea. In younger infants, ignorance acts as a safeguard against panic, but older children require some premedication for easy parental separation, IV cannulation, and spinal puncture. Midazolam, atropine, ketamine alone or in combination have been used by various routes (oral/rectal/IM) to provide sedation and anxiolysis. Per-rectal atropine (0.02 mg/kg) and midazolam (0.6 mg/kg) given 15 min prior to procedure, provides excellent sedation. [12]

Procedural sedation

Performing spinal puncture in a struggling, agitated child may injure delicate neurovascular structures and should be avoided. Most children require additional sedation (ketamine, midazolam, thiopentone, propofol, halothane, sevoflurane, or nitrous oxide). [11],[58] Infants may be soothened with flavored pacifiers or sucrose dipped dummy dip. [17] Concerns regarding increased risk of neurological injury during needle advancement in anesthetized children are unfounded. In fact, placement of blocks under GA is a standard practice and supported by many regional societies (e.g. French language study of regional anesthetists). [9] This study confirmed the low complication rate despite performance of 96% of blocks under GA/ heavy sedation. Intraoperative sedation may not be required if SA is successful because de-afferentiation itself produces sedation. This has been proven using bi-spectral index (BIS) in infants under SA. [59] Loose soft restraints may be applied to the wrists to prevent infant from reaching on to the sterile field. Some older children prefer not to be sedated, opting for music or watching a cartoon.

Technique - Conventionally, SA is performed in a lateral decubitus position, with patient curled up and flexed at neck and hip joint. In neonates and infants, care must be taken to avoid extreme neck flexion [Figure 4] because of resultant upper airway obstruction leading to hypoxia (decreased transcutaneous O 2 tension (TcpO 2 ) by almost 28 mmHg). [60] Both sitting and lateral positions have been found to be suitable. A 45° head up tilt may help by increasing the CSF pressure in infants. [61] Functional /hysterical scoliosis makes puncture more difficult. Depth of insertion at L 4-5 varies with age (newborn 10-15 mm, up to 5 years 15-25 mm, 5-8 years 30-40 mm). Distance from skin to subarachnoid space (mm) can be calculated by the formula {0.03 x height (cm)} or {2 x weight (kg) +7}. [62]
Figure 4: SA in an infant with head extension

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Recently, ultrasound has been increasingly used for neuraxial imaging in pediatric population. Though its use is mainly limited to epidural blocks, it may find its application for SA in future. In infants (<6 months age), excellent acoustic window for imaging can be obtained because their posterior spinal columns are incompletely ossified. [62] US imaging may help pediatric anesthesiologist in deciding the puncture point, planning needle trajectory, and gauge the depth of needle insertion from skin.

Reflux of CSF following puncture indicates that needle is in the right place. LA is injected over 20 second period. [17] As the volume of drug is small, needle and hub dead space (0.02-0.04 ml) should be taken into consideration when calculating the total volume. Caution should be taken not to elevate the lower extremities because of resultant high or "total" spinal anesthesia. [63] The neurological sequalae can be minimized using appropriate volume, baricity and concentration of drug, puncture site, ensuring free flow of CSF before injecting the drug, and avoiding micro-catheters.

Some pediatric anesthesiologists advocate establishing IV access in the lower limb after onset of block because of absence of hemodynamic instability following SA in infants. But, securing IV access prior to performing of block provides added safety. Oximeter probe and NIBP cuff may be applied to the lower extremity to avoid disturbing infants during surgery. Per-rectal acetaminophen and diclofenac suppositories may be inserted at the end of surgery to provide post-operative analgesia. Peripheral nerve blocks (penile or ilio-inguinal block) performed at the end of surgery may provide prolonged post-operative analgesia. [35]

Block assessment in children

In awake children, level of block can be ascertained by pinprick, finger pinch, forceps, and ice. In infants and sedated patients, transcutaneous electrical stimulation is a better and reproducible method. [51] In children requiring deep sedation or GA for performance of block, inability to move the blocked extremity after emergence is a good evidence of successful block. Motor block can be assessed by modified Bromage score and pain by FLACC (infants), CHEOPS (1-7 years), and Visual Analogue scale or VAS (older children) scales.

Advantages of SA over GA

  1. SA is a cheaper alternative in countries with limited resources, due to rapid recovery, shortened hospital stay, and more procedures performed on day care basis. Imbelloni et al. documented 54% reduction in cost as compared to GA (49$ vs. 105$). [13] Kokki et al. demonstrated a more rapid patient turnover rate in OR as secondary cost saving besides primary cost benefit. [64]
  2. SA provides all components of balanced anesthesia with minimum cardio-respiratory disturbances and PONV, early ambulation, and rapid return of appetite.
  3. Tracheal intubation and respiratory effects of GA and IV opioids can be avoided in high-risk patients (with subglottic stenosis, laryngo-tracheomalacia, difficult airway, muscular dystrophy, hyper-reactive airways, bullous epidermolysis) with limited respiratory reserve. [17],[21],[28],[32],[57]
  4. SA is more effective than GA or epidural block in blunting the neuroendocrine stress and adverse responses to surgery. [65] Plasma epinephrine, norepinephrine, lactate, and IL-6 levels are reduced, with improved outcome in neonates and infants undergoing cardiac and other major surgeries.
  5. SA is a preferred choice in a child at risk of developing malignant hyperthermia (MH) as amino amide LA can be used safely in MH susceptible patients. [17] Also, it is an alternative technique in patients with medical and respiratory diseases who are otherwise at high risk under GA. [61]
  6. Recent data from animal studies has raised concerns regarding safety of GA drugs on rapidly growing brain cells, especially in neonates and infants. [15] However, the neuraxial administration of drugs may also have harmful effects on the spinal cord in early stages of development. Though the literature is limited on this regard at present. [56]
  7. Environmental concerns about ozone layer depletion give an edge to SA over GA, because open tailed pediatric circuits are considered as one of the major contributors.


SA in ex-premature infants

SA has been termed as a 'Gold standard' technique in the former preterm infant (<60 weeks PCA) for lower abdominal and lower extremity surgeries under 90 minutes duration. [10],[51] These patients have an increased incidence of apnea (45% in <48 wks PCA), which is further increased because of associated broncho-pulmonary dysplasia, intracranial hemorrhage, and anemia. SA has been found to be associated with reduced incidence of apnea, bradycardia, desaturation, and post-operative ventilatory requirements in this group of patients. [6],[7],[8],[9],[10] Krane et al. (1995) confirmed a lower incidence of apnea under SA by pre- and post-operative pneumograms. [8] Cochrane meta-analysis also supported a reduction in apnea with SA in children who had not received sedatives and suggested the need for further large multi-centric trials to prove the effect. [66] However, decreased incidence of apnea does not preclude routine monitoring of these high-risk infants for 24 hours in PACU until further evidence proves the contrary.

Recovery and discharge

Before shifting the patient to recovery room, one must ensure stable vital signs, intact gag, swallowing and cough reflexes, and adequate respiration. Criteria for discharge should include ambulation (appropriate for age), orientation to time, place and person appropriate for child's age, tolerating oral fluids with minimal nausea, and vomiting. Voiding, though not necessary, helps establish fluid status and degree of residual block. [16] If residual sensory block is present, instructions to protect the child from hot, cold, or sharp objects should be given.

Side-effects and complications

Complications of SA in children are usually minor and infrequent [Table 2]. ADARPEF's prospective study in preterm to adolescent patients reported only one complication after 506 SA (IV injection). [9] Vermont spinal registry also confirmed the rare incidence of complications in infants. [10] No report in literature mentions any fatal complication or permanent neurological sequelae following SA. Some of the complications, which can occur include:

  • Cardio-respiratory insufficiency: Hypotension and desaturation are rare in children. If at all, it is usually due to high block or use of sedatives. One report mentions occurrence of bronchospasm with higher block. [13]
  • Post-dural puncture headache: PDPH was thought to be rare in children <10 years age, because of low CSF pressure, highly elastic dura and non-ambulation. Lately, it was reported in children as young as 2 years, suggesting that its occurrence is independent of age. [67] Overall incidence of 4-5% (as in adults) has been reported in 2-15 years age group. [17],[35] Symptoms are generally mild. Severe PDPH is very rare (0.1%). Treatment is conservative. Epidural blood patch (0.2-0.3 ml/kg) should be considered if headache persists for >1 week. [17] Results of studies comparing the effect of needle tip design on incidence of PDPH are contradictory. While earlier studies reported similar incidence of PDPH with pencil point and cutting needles, [36] recent article found lesser incidence with pencil point (0.4% vs. 5%). [68]
  • Backache: (5-10%) is a common complaint, but its causal relationship has not been established. [17]
  • High or total spinal anesthesia: (0.6%) can result if infant's legs are lifted after injection of drug or with overdose and barbotage. [10],[59] Limited thoracic kyphosis facilitates cephalad spread resulting in apnea, requiring assisted ventilation. [19]
  • Transient neurological symptoms: (3-4%) is described as new onset pain and dysesthesia originating in gluteal region and radiating to lower limbs. [17] In most cases, symptoms are mild. Neurological examination, imaging studies, and electro-pathological testing are usually negative. No TNS was observed in 307 patients undergoing surgeries under SA with 0.5% bupivacaine or 2% lignocaine. [13]
  • Infection: Only anecdotal reports of meningitis (aseptic and septic) are reported with SA in children, that too with no proven causal relationship. [69] In case of post-spinal fever, prompt LP is indicated for quick diagnosis.


Neurotoxicity potential of spinal additives

Many of the currently used spinal analgesic adjuvants have not undergone systematic evaluation of spinal neurotoxicity before their introduction into clinical practice. [70] Recently, effort has been there to define safety of neuraxially delivered drugs through pre-clinical models in adult animals, [71] but scarce data is available regarding their effect in early post-natal period. Similar to the potential pro-apoptotic effects of general anesthetics on developing brain, [15] even neuraxially administered agents can lead to increased apoptosis in developing spinal cord during rapid growth spurt. Intrathecal drugs can lead to specific patterns of toxicity by altering neural activity in cord. [70] Post-natal development of A and C- fiber innervations in spinal cord is activity-dependent and can be altered by changing input at critical phases of development. [72] Exposure to drugs that enhance inhibition may trigger excessive apoptosis. Ketamine has been shown to alter dendritic arborization of GABAergic neurons in-vitro, though direct in-vivo evaluation has not been done. [73] On the contrary, Dexmedetomidine, a novel alpha2 agonist, has been found to have neuroprotective effects in in-vivo and in-vitro animal spinal cord preparations. [74] Large information pertaining to neuraxial adjuvant use in human neonates and infants attests to its safety. But, it is important to realize that much of it reflects retrospective data with limited follow-up and morphological changes cannot be assessed to confirm their safety. Also, in young infants and preverbal children who are unable to report sensory symptoms and cannot walk, subtle sensory and motor symptoms may be missed. Also, underreporting because of fear of litigation cannot be ruled out.

Hence, in current scenario, a reasonable strategy would be to define therapeutic ratio of several drugs under similar condition and prefer a drug with higher ratio. [70] Recently, it was demonstrated that therapeutic ratio in early life was >300 for morphine and clonidine, but <1 for ketamine as increased apoptosis occurred in the same dose range as analgesia. [75],[76],[77] We should evaluate the novel and the existing spinal drugs for their safety and efficacy before their introduction into routine clinical practice.

Limitations: Despite several specific indications and advantages, this technique has some limitations:

  1. Single shot technique provides mere 70-80 minutes of surgical anesthesia and shorter post-operative analgesia. This can be overcome with judicious use of additives and CSE technique [Table 4].
  2. Need for sedation and GA in some children for performance of block and despite successful block during the surgery. This, however, should not be a deterrent to use of SA because of its proven benefits and safety. [9] In fact, there may be less risk of injury in an immobile child than in a child who is struggling during needle placement. However, sedation should be avoided in premature infants as far as possible because of the risks already mentioned.
  3. Technical difficulties: Lack of co-operation and their unique anatomical features make SA in children challenging. Bloody tap and difficulty in aspiration are associated with failure of SA. [6],[13],[61] Failure rates of 5-15% have been reported. However, many recent large studies have documented a good success rate. [12],[13],[14],[35] Technical difficulties and failure may thus be a matter of individual skill and experience.
  4. Pediatric spinal needles are expensive and may not be freely available. Standard adult needles can be used in school-going and older children, and with due care even in younger children (6 mth-1 year). [12],[17],[37]



  Conclusion Top


Today, more than a century ahead since its inception, although firmly established as safe, SA still remains underutilized in children. Based upon extensive literature review and our own experience, we are convinced that SA is safe, cost-effective, and technically feasible technique. It has a remarkable safety record in pediatric population in the hands of an experienced anesthetist, proper patient selection, drugs, and dosages. As anesthetists become more experienced, it may well become a preferred choice either alone or as a part of balanced technique in children undergoing elective surgeries, rather than just as an alternative in the high-risk pediatric patients.

 
  References Top

1.Bier A. Experiment regarding the cocainization of the spinal cord. Zentralbl Chir 1899;51:361-9.   Back to cited text no. 1
    
2.Bainbridge WS. A report of twelve operations on infants and young children during spinal anesthesia. Arch Pediatr 1901;18:570-4.  Back to cited text no. 2
    
3.Gray HT. A study of subarachnoid block in children and infants. Lancet 1909;2:913-7.   Back to cited text no. 3
    
4.Berkowitz S, Greene BA. Spinal anaesthesia in children: Report based on 350 patients under 13 years. Anesthesiology 1951;12:376-87.  Back to cited text no. 4
[PUBMED]    
5.Junkin CI. Spinal anaesthesia in children. Can Med Assoc J 1933;28:51-3.   Back to cited text no. 5
[PUBMED]    
6.Abajian JC, Mellish RW, Browne AF, Perkins FM, Lambert DH, Mazuzan JE Jr. Spinal anesthesia for surgery in the high- risk infant. Anesth Analg 1984;63:359-62.   Back to cited text no. 6
[PUBMED]    
7.Williams JM, Stoddart PA, Williams SA, Wolf AR. Postoperative recovery after inguinal herniotomy in ex-premature infants: Comparison between sevoflurane and spinal anesthesia. Br J Anaesth 2001;86:366-71.  Back to cited text no. 7
    
8.Krane EJ. Harberkern CM, Jacobson LE. Postoperative apnea, bradycardia and oxygen desaturation in formerly premature infants: Prospective comparison of spinal and general anesthesia. Anesth Analg 1995;80:7-13.   Back to cited text no. 8
    
9.Ecoffey C, Lacroix F, Giaufré E, Orliaguet G, Courrèges P, Association des Anesthésistes Réanimateurs Pédiatriques d'Expression Française (ADARPEF). Epidemilogy and morbidity of regional anesthesia in children: A follow-up one-year prospective survey of the French-Language Society of Pediatric Anesthesiologists (ADARPEF). Paediatr Anaesth 2010;20:1061-9.  Back to cited text no. 9
    
10.Williams RK, Adams DC, Aladjem EV, Kreutz JM, Sartorelli KH, Vane DW, et al. The safety and efficacy of spinal anesthesia for surgery in infants: The Vermont Infant Spinal Registry. Anesth Analg 2006;102:67-71.  Back to cited text no. 10
[PUBMED]    
11.Kokki H, Heikkinen M, Ahonen R. Recovery after paediatric day case herniotomy performed under spinal anaesthesia. Pediatr Anesth 2000;10:413-7.   Back to cited text no. 11
    
12.Puncuh F, Lampugnani E, Kokki H. Use of spinal anesthesia in pediatric patients: A single centre experience with 1132 cases. Pediatr Anesth 2004;14:564-7.  Back to cited text no. 12
    
13.Imbelloni LE, Vieira EM, Sperni F, Guizellini RH, Tolentino AP. Spinal anesthesia in children with isobaric local anesthetics: Report on 307 patients under 13 years of age. Pediatr Anaesth 2006;16:43-8.   Back to cited text no. 13
    
14.Kachko L, Simhi E, Tzeitlin E, Efrat R, Tarabikin E, Peled E, et al. Spinal anesthesia in neonates and infants - a single-center experience of 505 cases. Paediatr Anaesth 2007;17:647-53.  Back to cited text no. 14
    
15.Olney JW, Young C, Wozniak DF, Ikonomidou C, Jevtovic-Todorovic V. Anesthesia induced developmental neuroapoptosis: Does it happen in humans? Anesthesiology 2004;101:273-5.  Back to cited text no. 15
    
16.Geiduschek JM. Pediatrics. In: Brown DL, editor. Regional anaesthesia and analgesia.1 st ed. Philadelphia: WB Saunders Company; 1996. p. 559-62.   Back to cited text no. 16
    
17.Kokki H. Spinal blocks. Paediatr Anaesth 2012;22:56-64.  Back to cited text no. 17
    
18.Hirabayashi Y, Shimizu R, Saitoh K, Fukuda H. Spread of subarachnoid hyperbaric amethocaine in adolescents. Br J Anaesth 1995;74:41-5.  Back to cited text no. 18
[PUBMED]    
19.Dohi S, Seino H. Spinal anesthesia in premature infants: Dosage and effects of sympathectomy. Anesthesiology 1986;65:559-61.  Back to cited text no. 19
[PUBMED]    
20.Pascucci RC, Hershenson MB, Sethna NF, Loring SH, Stark AR. Chest wall motion of infants during spinal anaesthesia. J Appl Physiol (1985) 1990;68:2087-91.  Back to cited text no. 20
    
21.Williams RK, McBride WJ, Abajian JC. Combined spinal and epidural anesthesia for major abdominal surgery in infants. Can J Anaesth 1997;44:511-4.  Back to cited text no. 21
[PUBMED]    
22.Gupta A, Saha U, Sinha SK, Gupta N. Subarachanoid block (SAB) versus general anaesthesia (GA) in children undergoing surgeries below umbilicus. J Anaesthesiol Clin Pharmacol 2008;24:425-8.   Back to cited text no. 22
  Medknow Journal  
23.William RK, Abajian JC. High spinal anaesthesia for repair of patient ductus arterious in neonates. Paediatr Anaesth 1997;7:205-9.  Back to cited text no. 23
    
24.Kowalewski R, MacAdams C, Frelich J, Neil S, Maitland A. Anaesthesia supplement with subarachnoid bupivacaine and morphine for coronary artery bypass surgery in a child with Kawasaki disease. J Cardiothorac Vasc Anesth 1996;10:243-6.  Back to cited text no. 24
    
25.Calvert DG. Direct spinal anesthesia for repair of myelomeningocele. Br Med J 1996;2:86-7.  Back to cited text no. 25
    
26.Aronsson DD, Gemery JM, Abajian JC. Spinal anesthesia for spine and lower extremity surgery in infants. J Pediatr Orthop 1996;16:259-63.  Back to cited text no. 26
[PUBMED]    
27.Viscomi CM, Abajian JC, Wald SL, Rathmell JP, Wilson JT. Spinal anesthesia for repair of meningomyelocele in neonates. Anesth Analg 1995;81:492-5.  Back to cited text no. 27
[PUBMED]    
28.Dallens BJ, Khandwala RS, Tanguy A. Staged segmental scoliosis surgery during regional anesthesia in high risk patients: A report of six cases. Anesth Analg 1993;76:434-9.  Back to cited text no. 28
    
29.Tobias JD. Anesthetic care for the child of Morquio Syndrome: General versus regional anesthesia. J Clin Anesth 1999;11:242-6.  Back to cited text no. 29
[PUBMED]    
30.O'Higashi T, Shirakami G, Sasai S, Shinomura T, Kato S, Tomoda K. Spinal anesthesia for patients with progressive muscular dystrophy. [Article in Japanese]. Masui 1995;44:723-8.  Back to cited text no. 30
    
31.Gingrich Bk. Spinal anesthesia for a former preterm infant undergoing upper abdominal surgery. Anesthesiology 1993;79:189-90.  Back to cited text no. 31
    
32.Arora MK, Nagaraja G, Lakhe ST. Combined spinal-epidural anesthetic for a child with Freeman-Sheldon syndrome with difficult airway. Anesth Analg 2006;103:1624.  Back to cited text no. 32
    
33.Spencer HT, Barnes PJ. Spinal anesthesia for pediatric radiotherapy. Anaesth Intensive Care 1980;8:214-6.  Back to cited text no. 33
    
34.Berde C, Sethna NF, Conrad LS, Hershenson MB, Shillito J Jr. Subarachanoid bupivacaine analgesia for seven months for a patient with a spinal cord tumor. Anesthesiology 1990;72:1094-6.  Back to cited text no. 34
    
35.Kokki H, Turunen M, Heikkinen M, Reinikainen M, Laisalmi M. High success rate and low incidence of headache and neurological symptoms with two spinal needle designs in children. Acta Anaesthesiol Scand 2005;49:1367-72.  Back to cited text no. 35
    
36.Kokki H, Heikkinen M, Turunen M, Vanamo K, Hendolin H. Needle design does not affect the success rate of spinal anaestheisa or the incidence of postpuncture complications in children. Acta Anaesthesiol Scand 2000;44:210-3.  Back to cited text no. 36
[PUBMED]    
37.Kokki H, Hendolin H. Comparison of 25G and 29G Quincke spinal needles in pediatrics day care surgery. A prospective randomized study of puncture characteristics, success rate and postoperative complaints. Paed Anesth 1996;6:115-9.  Back to cited text no. 37
    
38.Shaywitz BA. Epidermoid spinal cord tumors and previous lumbar punctures. J Pediatr 1972;80:638-40.  Back to cited text no. 38
[PUBMED]    
39.Kokki H, Ylönen P, Laisalmi M, Heikkinen M, Reinikainen M. Isobaric ropivacaine 5 mg/ml for spinal anaesthesia in children. Anesth Analg 2005;100:66-70.  Back to cited text no. 39
    
40.Kokki H, Ylönen P, Heikkinen M, Reinikainen M. Levobupivacaine for paediatric spinal anesthesia. Anesth Analg 2004;98:64-7.   Back to cited text no. 40
    
41.Frawley G, Smith KR, Ingelmo P. Relative potencies of bupivacaine, levobupivacaine, and ropivacaine for neonatal spinal anaesthesia. Br J Anaesth 2009;103:731-8.  Back to cited text no. 41
[PUBMED]    
42.Kokki H, Tuovinen K, Hendolin H. Spinal anaesthesia for pediatric day-case surgery: A double blind, randomized, parallel group, prospective comparison of isobaric and hyperbaric bupivacaine. Br J Anaesth 1998;81:502-6.  Back to cited text no. 42
[PUBMED]    
43.Rice LJ, DeMars PD, Whalen TV, Crooms JC, Parkinson SK. Duration of spinal anesthesia in infants less than one year of age. Comparison of three hyperbaric techniques. Reg Anesth 1994;19:325-9.  Back to cited text no. 43
[PUBMED]    
44.Fösel T, Wilhelm W, Grüness V, Molter G. Spinal anesthesia in infancy using 0.5% bupivacaine: The effect of adrenaline addition on duration and haemodynamics. Anaesthesist 1994;43:26-9.  Back to cited text no. 44
    
45.Ganesh A, Kim A, Casale P, Cucchiaro G. Low dose intrathecal morphine for postoperative analgesia in children. Anesth Analg 2007;104:271-6.  Back to cited text no. 45
[PUBMED]    
46.Finkel JC, Doyle JM, Conran AM. A comparison of three intrathecal morphine doses during SA in children having open heart surgery. Anesthesiology 1997;87:A1052.   Back to cited text no. 46
    
47.Eschertzhuber S, Hohlrieder M, Keller C, Oswald E, Kuehbacher G, Innerhofer P. Comparison of high- and low-dose intrathecal morphine for spinal fusion in children. Br J Anaesth 2008;100:538-43.  Back to cited text no. 47
[PUBMED]    
48.Piral A, Akpek E, Arslam G. Intrathecal versus 4 fentanyl in pediatric cardiac anaesthesia. Anesth Analg 2002;95:1207-14.  Back to cited text no. 48
    
49.Batra YK, Lokesh VC, Panda NB, Rajeev S, Rao KL. Dose-response study of intrathecal fentanyl added to bupivacaine in infants undergoing lower abdominal and urologic surgery. Paediatr Anaesth 2008;18:613-9.  Back to cited text no. 49
[PUBMED]    
50.Duman A, Apiliogullari S, Duman I. Effects of intrathecal fentanyl on quality of spinal anesthesia in children undergoing inguinal hernia repair. Paediatr Anaesth 2010;20:530-6.  Back to cited text no. 50
[PUBMED]    
51.Rochette A, Raux O, Troncin R, Dadure C, Verdier R, Capdevila X. Clonidine prolongs spinal anesthesia in newborns: A prospective dose ranging study. Anesth Analg 2004;98:56-9.  Back to cited text no. 51
[PUBMED]    
52.Kaabachi O, Zarghouni A, Ouezini R, Abdelaziz AB, Chattaoui O, Kokki H. Clonidine 1 microgram/kg is a safe and effective adjuvant to plain bupivacaine in spinal anesthesia in adolescents. Anesth Analg 2007;105:516-9.  Back to cited text no. 52
[PUBMED]    
53.Cao JP, Miao XY, Liu J, Shi XY. An evaluation of intrathecal bupivacaine combined with intrathecal or intravenous clonidine in children undergoing orthopedic surgery: A randomized double-blinded study. Paediatr Anaesth 2011;21:399-405.  Back to cited text no. 53
[PUBMED]    
54.Batra YK, Rajeev S, Panda NB, Lokesh VC, Rao KL. Intrathecal neostigmine with bupivacaine for infants undergoing lower abdominal and urogenital procedures: Dose response. Acta Anesthesiol Scand 2009;53:470-5.  Back to cited text no. 54
    
55.Goldman LJ. Complications in regional anaesthesia. Paediatr Anaesth 1995;5:3-9.   Back to cited text no. 55
[PUBMED]    
56.Walker SM, Yaksh TL. Neuraxial analgesia in neonates and infants: A review of clinical and preclinical strategies for the development of safety and efficacy data. Anesth Analg 2012;115:638-62.  Back to cited text no. 56
[PUBMED]    
57.Nickel US, Meyer RR, Brambrink AM. Spinal anesthesia in an extremely low birth weight infant. Paediatr Anaesth 2005;15:58-62.   Back to cited text no. 57
[PUBMED]    
58.Singh R, Batra YK, Bharti N, Panda NB. Comparison of propofol versus propofol-ketamine combination for sedation during spinal anesthesia in children: Randomized clinical trial of efficacy and safety. Paediatr Anaesth 2010;20:439-44.  Back to cited text no. 58
[PUBMED]    
59.Hermanns H, Stevens MF, Werdehausen R, Braun S, Lipfert P, Jetzek-Zader M. Sedation during spinal anaesthesia in infants. Br J Anaesth 2006;97:308-4.  Back to cited text no. 59
    
60.Gleason CA, Martin RJ, Anderson JV, Carlo WA, Sanniti KJ, Fanaroff AA. Optimal position for a spinal tap in preterm infants. Pediatrics 1983;71:31-5.  Back to cited text no. 60
[PUBMED]    
61.López T, Sánchez FJ, Garzón JC, Muriel C. Spinal anesthesia in pediatric patients. Minerva Anestesiol 2012;78:78-87.  Back to cited text no. 61
    
62.Arthrus OJ, Murray M, Zubier M, Tooley J, Kelsall W. Ultrasongraphic determination of neonatal spinal canal depth. Arch Dis Child Fetal Neonatal Ed 2008;93:F451-4.  Back to cited text no. 62
    
63.Wright TE, Orr RJ, Haberkern CM, Walbergh EJ. Complications during spinal anesthesia in infants: High spinal blockade. HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/2104528" \o nesthesiology." Anesthesiology 1990;73:1290-2.  Back to cited text no. 63
    
64.Kokki H, Hendolin H. Vainis J. Operation im Vorschlater: Vergleich Von spinal anaesthesia ind allegemein anaesthestics. Anaesthesist 1992;41:765-8.  Back to cited text no. 64
    
65.Wolf AR, Doyle E, Thomas E. Modifying infants stress responses to major surgery: Spinal vs extradural vs opioid analgesia. Paediatr Anaesth 1998;8:305-11.   Back to cited text no. 65
[PUBMED]    
66.Craven PD, Badawi N, Henderson-Smart DJ, O'Brien M. Regional (spinal, epidural, caudal) versus general anaesthesia in preterm infants undergoing inguinal herniorrhaphy in early infancy. Cochrane Database Syst Rev 2003;3:CD003669.  Back to cited text no. 66
[PUBMED]    
67.Kokki H, Sakonvaara M, Herrgård E, Onen P. Postdural puncture headache is not an age-related symptom in children: A prospective, open-randomised, parallel group study comparing a 22-gauge Quincke with a 22-gauge Whitacre needle. Paediatr Anaesth 1999;9:429-34.  Back to cited text no. 67
    
68.Apiliogullari S, Duman A, Gok F, Akillioglu I. Spinal needle design and size affect the incidence of postdural puncture headache in children. Paediatr Anaesth 2010;20:177-82.  Back to cited text no. 68
[PUBMED]    
69.Lauriala JJ, Lostamovaara PA, Alahuhta S. Streptococcus Salivarius meningitis after spinal anaesthesia in an infant. Anesthesiology 1998;19:1579-80.   Back to cited text no. 69
    
70.Walker SM, Yaksh TL. Neuraxial analgesia in neonates and infants: A review of clinical and preclinical strategies for the development of safety and efficacy data. Anesth Analg 2012;115:638-62.  Back to cited text no. 70
[PUBMED]    
71.Yaksh TL, Rathbun ML, Provencher JC. Preclinical safety evaluation for spinal drugs. In: Yaksh TL, editor. Spinal Drug Delivery. Amsterdam: Elsevier Science B.V.; 1999. p. 417-37.  Back to cited text no. 71
    
72.Torsney C, Meredith-Middleton J, Fitzgerald M. Neonatal capsaicin treatment prevents the normal postnatal withdrawal of A fibres from lamina II without affecting fos responses to innocuous peripheral stimulation. Brain Res Dev Brain Res 2000;121:55-65.  Back to cited text no. 72
[PUBMED]    
73.Vutskits L, Gascon E, Tassonyi E, Kiss JZ. Effect of ketamine on dendritic arbor development and survival of immature GABAergic neurons in vitro. Toxicol Sci 2006;91:540-9.  Back to cited text no. 73
[PUBMED]    
74.Zhang H, Zhou F, Li C, Kong M, Liu H, Zhang P, et al. Molecular mechanisms underlying the analgesic property of intrathecal dexmedetomidine and its neurotoxicity evaluation: An in vivo and in vitro experimental study. PLoS One 2013;8:e55556.  Back to cited text no. 74
[PUBMED]    
75.Westin BD, Walker SM, Deumens R, Grafe M, Yaksh TL. Validation of a preclinical spinal safety model: Effects of intrathecal morphine in the neonatal rat. Anesthesiology 2010;113:183-99.  Back to cited text no. 75
[PUBMED]    
76.Walker SM, Grafe M, Yaksh TL. Intrathecal clonidine in the neonatal rat: Dose-dependent analgesia and evaluation of spinal apoptosis and toxicity. Anesth Analg 2012;115:450-60.  Back to cited text no. 76
[PUBMED]    
77.Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL. Effects of intrathecal ketamine in the neonatal rat: Evaluation of apoptosis and long-term functional outcome. Anesthesiology 2010;113:147-59.  Back to cited text no. 77
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]
 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4]


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