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CASE REPORT
Year : 2014  |  Volume : 30  |  Issue : 1  |  Page : 89-90

Platelet cold agglutinins and thrombocytopenia: A diagnostic dilemma in the intensive care unit


1 Department of Anaesthesia, Fortis Hospitals, Bangalore, Karnataka, India
2 Department of Anesthesia & Intensive Care, Post Graduate Institute of Medical Education & Research, Chandigarh, India

Correspondence Address:
TV Bharath Kumar
1554, 16th Main, JP Nagar, 2nd Phase, Bangalore - 560 078, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9185.125711

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We report a case of pseudo-thrombocytopenia due to cold agglutinins against platelets. These cold agglutinins were the cause for diagnostic confusion and resulted in extensive workup and unnecessary therapeutic precautions. A thirty two year old female with Guillain-Barre syndrome was admitted in the ICU and serial work-up showed markedly low levels of platelets. The patient had no symptoms of bleeding and patient was investigated extensively for deciphering the etiology of low platelet count. In-vitro clumping of platelets was suspected and in-vitro studies showed marked clumping of platelets with ethylene-diamine-tetra-acetic acid, citrate and heparinized samples. The manual platelet count was found to be within normal limits. Thrombocytopenia as a result of platelet cold agglutinins is a rare cause of in-vitro low platelet counts. No clinical problems have been reported due to the same.


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