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Table of Contents
Year : 2015  |  Volume : 31  |  Issue : 2  |  Page : 266-268

A rare case of postpoliomyelitis quadriparetic patient with severe kyphoscoliosis

Department of Anaesthesia and Intensive Care, Government Medical College and Hospital, Chandigarh, India

Date of Web Publication16-Apr-2015

Correspondence Address:
Vanita Ahuja
Department of Anaesthesia and Intensive Care, Government Medical College and Hospital, Sector 32, Chandigarh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9185.155206

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How to cite this article:
Ahuja V, Gombar S, Singla D. A rare case of postpoliomyelitis quadriparetic patient with severe kyphoscoliosis. J Anaesthesiol Clin Pharmacol 2015;31:266-8

How to cite this URL:
Ahuja V, Gombar S, Singla D. A rare case of postpoliomyelitis quadriparetic patient with severe kyphoscoliosis. J Anaesthesiol Clin Pharmacol [serial online] 2015 [cited 2020 May 31];31:266-8. Available from:

To the Editor,

Poliomyelitis is an acute, paralytic viral infection caused by enterovirus. The virus is transmitted through fecal-oral route to lymph nodes as its primary site where it replicates and then enters the bloodstream. Paralytic poliomyelitis globally is on the verge of eradication except for few developing countries. [1] The virus enters central nervous system in 1-2% [2] of cases which may progress to permanent flaccid paralysis, also known as postpolio residual paralysis (PPRP). Quadriparesis occurs in 1.4% and kyphoscoliosis in 12% of patients of PPRP. [2],[3] In the modern era, it is very rare to encounter adult patients with quadriparesis and severe kyphoscoliosis following PPRP.

A written informed consent was obtained from patient for scientific publication of this case report along with radiological images.

A 26-year-old female, with a history of severe kyphoscoliosis and neglected limb deformities following PPRP [Figure 1]was scheduled for total abdominal hysterectomy under general anesthesia (GA). She was a diagnosed case of poliomyelitis at the age of 6 months. Ever since then, the patient was nonambulatory and was confined to a wheelchair. She had a past history of pulmonary tuberculosis 12 years back for which she took antitubercular treatment with no relapse.
Figure 1: General physical appearance of the patient showing neglected limb deformities following postpolio residual paralysis

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On physical examination, the patient was short stature, 130 cm height and 28 kg of weight. Neurological examination revealed normal higher function, no sensory deficit, reduced power of 2/5 in upper limbs and absent power in lower limbs. Musculoskeletal examination revealed severe kyphoscoliosis of thoraco-lumbar spine and severe atrophy of limb muscles. There was fixed flexion deformity of both hip joints leading to exaggerated lumbar lordosis. She had normal sensory functions with intact bowel and bladder control. Examination of respiratory and cardiovascular system was unremarkable. Airway examination was normal with normal neck movements and a Mallampati Class 1.

The blood biochemistry was within the normal limits. Chest X-ray revealed severe thoraco-lumbar scoliosis with right-sided curve and Cobb's angle of approximately 140-150° [Figure 2]. Arterial blood gas analysis showed pH 7.40, pO 2 99.8 mmHg, pCO 2 34.0 mmHg, HCO 3 20.9 mmol/L, base deficit −4.0 and SpO 2 98.2%. Breath holding time of the patient was 25 s. Patient was unable to perform pulmonary function test (PFT) in spite of repeated explaining. Arterial blood gas analysis showed normal values. Echocardiography was normal with ejection fraction of 60% with no pulmonary arterial hypertension. Computed tomography scan abdomen showed right ovarian cystic mass with severe kyphoscoliosis and badly rotated spine. Patient preferred GA for the surgical procedure. Patient was premedicated with oral ranitidine 150 mg night before and 2 h prior to surgery.
Figure 2: Anteroposterior X-ray showing severe thoraco-lumbar scoliosis with a badly rotated spine

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In operating theater mandatory anesthesia monitoring was established. The patient had inability to lie supine; hence the surgical position was made by keeping pillows under both the knees and a wedge under the right hip. An 18 G intravenous (IV) cannula was inserted in a peripheral vein of left hand and normal saline fluid was started. A right radial artery cannulation was done under local anesthesia. After preoxygenation, IV thiopentone sodium 4 mg/kg, fentanyl 2 μg/kg and IV atracurium 0.5 mg/kg were administered. Endotracheal intubation was done with 7.0 mm internal diameter cuffed endotracheal tube and anesthesia was maintained with isoflurane 0.8-1.5% with O 2 in air 40:60. Antihypothermia measures were taken using warming blanket and warm IV fluids. Intermittent boluses of IV atracuruim 0.1 mg/kg were administered according to neuromuscular monitoring. Surgery lasted for 1.5 hrs. At the end of surgery, bilateral tranversus abdominal block with 10 ml 0.25% bupivacaine with 2 μ/ml fentanyl was performed on each side. Residual neuromuscular blockade was reversed with IV neostigmine 0.05 mg/kg and glycopyrrolate 100 μg/kg after confirming a train of four of 0.9. Trachea was extubated and patient was shifted to intensive care unit for postoperative management. IV diclofenac 50 mg in infusion twice daily and paracetamol 500 mg six hourly were given for postoperative pain relief. Patient had an uneventful postoperative period and was discharged home after 1-week of hospital stay.

This is the first reported case of peri-operative management of patient with quadriparesis, severe kyphoscoliosis and neglected deformities following PPRP scheduled for noncorrective surgery under GA.

The present case had several challenges: Firstly, patient had severe kyphoscoliosis with muscle atrophy and limb contractures following PPRP. Secondly, there was difficulty in positioning of patient in the operating room and thirdly, anesthetic choice of drugs. A Cobbs' angle of >100° suggests significant pulmonary and cardiac changes. These include restrictive pattern of lung function, decrease in functional residual capacity, total lung capacity and vital capacity though, residual volume may remain normal. These patients in severe cases may progress to pulmonary hypertension and cor pulmonale. [4] PFTs were not done in the present case due to noncompliance. However, the patient had normal arterial blood gas values and echocardiography showed normal study. Special posture related care is important in these patients having musculoskeletal deformities as these patients may not be able to lie supine or lateral, which may be desired for surgery. We took special care to avoid position related injuries in peri-operative period and no neurological deficit occurred in our patient. [5]

A detailed history during preoperative evaluation should focus on history of sleep apnea, daytime fatigue and snoring and if present, it predisposes such patients to a five times higher risk of apnea in the postoperative period. [5] There was no such history in our patient. Patient's with PPRP are at an increased risk of aspiration and apnea due to delayed gastric emptying and weakness of pharyngeal and laryngeal muscles. [6],[7],[8]

Similarly, severe deformities and prolonged immobilization predisposes these patients to extreme sensitivity of peri-operative medications and their adverse effects. [9] Hence, dose of induction agents, opioids, and inhational agents were titrated carefully in the present case. [10],[11]

During GA, the dose of muscle relaxant was guided with neuromuscular monitoring. Succinylcholine should be used cautiously. However, short acting muscle relaxants like atracurium, mivacurium are preferred. [2],[11] Extubation of trachea was done after patient was fully awake with complete reversal of NM blockade so as to avoid respiratory complications, which are quite common in patients with muscle weakness and PPRP. [12]

Cold intolerance is another peri-operative problem commonly seen in such patients. [6] The exact mechanism is not clear, but could be due to loss of vasoconstrictor sympathetic supply or alterations in blood supply to the atrophied muscles. [12] Antihypothermia measures should be used in the peri-operative period.

Regional anesthesia in the present case was not a viable option due to anatomical deformities and patient's preference for GA. Use of regional anesthesia in these patients needs individualization due to the damaged neurons, increased sensitivity to local anesthetics, technical difficulty and unpredictable spread of the local anesthetic. [2],[13],[14]

Regional blocks are preferred over opioids to avoid sedation and respiratory depression for postoperative pain relief. [10] Nonsteroidal antiinflammatory drugs and paracetamol are safe and can be used. [12]

Thus to conclude, the anesthetic management of the present patient was challenging, but successful due to meticulously executed peri-operative care.

  References Top

Schuchat A. The state of immunization 2013: We are the world. S D Med 2013;Spec no:27-32.  Back to cited text no. 1
Lambert DA, Giannouli E, Schmidt BJ. Postpolio syndrome and anesthesia. Anesthesiology 2005;103:638-44.  Back to cited text no. 2
Srivastava VK, Laisram N, Srivastava RK. Immunization status in paralytic poliomyelitis - A hospital based study. Indian Pediatr 1989;26:430-3.  Back to cited text no. 3
Jagadeesh A, Manjunath N, Rao VR, Sathyakumari SA. Anaesthetic management of closed mitral valvotomy for severe mitral stenosis with traumatic kyphoscoliosis. Indian J Anaesth 2010;54:62-4.  Back to cited text no. 4
[PUBMED]  Medknow Journal  
Fischer DA. Sleep-disordered breathing as a late effect of poliomyelitis. Birth Defects Orig Artic Ser 1987;23:115-20.  Back to cited text no. 5
Buchholz DW, Jones B. Post-polio dysphagia: Alarm or caution? Orthopedics 1991;14:1303-5.  Back to cited text no. 6
Sonies BC, Dalakas MC. Dysphagia in patients with the post-polio syndrome. N Engl J Med 1991;324:1162-7.  Back to cited text no. 7
Driscoll BP, Gracco C, Coelho C, Goldstein J, Oshima K, Tierney E, et al. Laryngeal function in postpolio patients. Laryngoscope 1995;105:35-41.  Back to cited text no. 8
Bruno RL, Cohen JM, Galski T, Frick NM. The neuroanatomy of post-polio fatigue. Arch Phys Med Rehabil 1994;75:498-504.  Back to cited text no. 9
Schwartz JJ. Skin and musculoskeletal diseases. In: Paul AK, adapting editor. Stoelting's Anesthesia and Co-existing Disease. 5 th ed. India: Elsevier; 2010. p. 505.  Back to cited text no. 10
Gyermek L. Increased potency of nondepolarizing relaxants after poliomyelitis. J Clin Pharmacol 1990;30:170-3.  Back to cited text no. 11
Magi E, Recine C, Klockenbusch B, Cascianini EA. A postoperative respiratory arrest in a post poliomyelitis patient. Anaesthesia 2003;58:98-9.  Back to cited text no. 12
Hebl JR, Horlocker TT, Schroeder DR. Neuraxial anesthesia and analgesia in patients with preexisting central nervous system disorders. Anesth Analg 2006;103:223-8.  Back to cited text no. 13
Costello JF, Balki M. Cesarean delivery under ultrasound-guided spinal anesthesia [corrected] in a parturient with poliomyelitis and Harrington instrumentation. Can J Anaesth 2008;55:606-11.  Back to cited text no. 14


  [Figure 1], [Figure 2]


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