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REVIEW ARTICLE
Year : 2016  |  Volume : 32  |  Issue : 2  |  Page : 160-167

Intravenous sub-anesthetic ketamine for perioperative analgesia


Department of Anesthesiology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA

Correspondence Address:
Andrew W Gorlin
Department of Anesthesiology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9185.182085

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Ketamine, an N-methyl-d-aspartate antagonist, blunts central pain sensitization at sub-anesthetic doses (0.3 mg/kg or less) and has been studied extensively as an adjunct for perioperative analgesia. At sub-anesthetic doses, ketamine has a minimal physiologic impact though it is associated with a low incidence of mild psychomimetic symptoms as well as nystagmus and double vision. Contraindications to its use do exist and due to ketamine's metabolism, caution should be exercised in patients with renal or hepatic dysfunction. Sub-anesthetic ketamine improves pain scores and reduces perioperative opioid consumption in a broad range of surgical procedures. In addition, there is evidence that ketamine may be useful in patients with opioid tolerance and for preventing chronic postsurgical pain.


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