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ORIGINAL ARTICLE
Year : 2016  |  Volume : 32  |  Issue : 4  |  Page : 476-482

The effect of pregabalin and s-ketamine in total knee arthroplasty patients: A randomized trial


1 Department of Anesthesiology, Pain and Palliative Medicine, Radboud University, Nijmegen Medical Centre, The Netherlands
2 Department of Orthopaedics, Pain and Palliative Medicine, Radboud University, Nijmegen Medical Centre, The Netherlands

Correspondence Address:
Lajla Kadic
Department of Anesthesiology, Pain and Palliative Medicine, Radboud University, Nijmegen Medical Centre, Postbus 9101, 6500 HB Nijmegen
The Netherlands
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9185.194762

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Background and Aims: Pain reduction is important for rehabilitation after total knee arthroplasty. Intra- and peri-articular infiltration with local anesthetics may be an alternative to commonly used locoregional techniques. Adding pregabalin orally and s-ketamine intravenously may further reduce postoperative pain. Material and Methods: This prospective, randomized, double-blind, placebo-controlled study compared two methods of perioperative analgesia. Control patients received a standardized multimodal postoperative analgesic regime of paracetamol, diclofenac, and piritramide-patient-controlled analgesia, including ropivacaine knee infiltration during surgery. The study group received pregabalin orally and s-ketamine intravenously as an additional medication to the standard multimodal regimen. The control group received placebo. Results: The study group showed lower piritramide consumption during the first 24 h (P: 0.043), but with more side effects such as diplopia and dizziness. Conclusion: Addition of pregabalin and s-ketamine resulted in lower piritramide consumption during the first 24 h postoperatively. However, more investigation on benefits versus side effects of this medication is required.


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