A prospective observational study of the use of desflurane anesthesia in Indian adult inpatients undergoing surgery: The Registry in India on Suprane Emergence registry
Mukul Chandra Kapoor1, M Radhakrishnan2, VJ Ramesh2, HS Murthy3, Dhirja Sharma4, Parameswara Gundappa3, Tanmoy Das5, Ravi Wankhede5, K Bhaskaran6, Saiket Sengupta5, Rajendrasingh Patil7, Sibasish Dey8, Kuljinder Singh8, Ashok K Moharana8
1 Department of Anaesthesia, Max Smart Super Specialty Hospital, Saket, Delhi, India
2 Department of Anaesthesia, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
3 Department of Anaesthesia, Manipal Hospital, Bengaluru, Karnataka, India
4 Department of Anaesthesia, Max Super Speciality Hospital, Shalimar Bagh, Delhi, India
5 Department of Anaesthesia, Apollo Gleneagles Hospitals, Kolkata, West Bengal, India
6 Department of Anaesthesia, Apollo Hospitals, Chennai, Tamil Nadu, India
7 Department of Anaesthesia, Ruby Hall Clinic, Pune, Maharashtra, India
8 Medical Affairs, Baxter Private Limited, Gurgaon, Haryana, India
Mukul Chandra Kapoor
Department of Anaesthesia, Max Smart Super Specialty Hospital, Mandir Marg, Press Enclave Road, Saket, New Delhi - 110 017
Source of Support: None, Conflict of Interest: None
Background and Aims: Limited registry studies are available on the use of anesthetic agents. This registry was conducted to evaluate emergence outcomes in Indian adult patients undergoing surgery with desflurane anesthesia.
Material and Methods: This multicenter, prospective, non-interventional, observational study (Registry in India on Suprane Emergence [RISE] registry) included adult inpatients who received desflurane as general anesthetic for surgical procedure of ≥2 h. Patients were stratified by age into three groups: ≥18–40 years, ≥41–65 years, and >65 years. Data on patients' demographics, practice, and usage pattern of medications were collected. The primary efficacy outcomes were time to extubation, time to response to verbal command, and time to orientation.
Results: Of 236 patients screened, 201 (≥18–40 years, n = 70; ≥41–65 years, n = 65; >65 years, n = 66) were enrolled in the study. Mean time to extubation observed in ≥18–40 years group was 7.2 ± 4.1 min, ≥41–65 years was 11.6 ± 8.99 min, and >65 years was 12.0 ± 10.5 min. Mean time to response to verbal command was 7.4 ± 4.3 min for ≥18–40 years, 10.9 ± 8.5 min for ≥41–65 years, and 10.0 ± 5.4 min for >65 years. Mean time to orientation was 13.0 ± 7.0 min for ≥18–40 years, 16.1 ± 12.0 min for ≥41–65 years, and 17.0 ± 8.6 min for >65 years. Incidence of nausea and retching/vomiting was observed in 8% of patients each in the postoperative period, and these complications were seen more in the >65 years age group. Overall, desflurane treatment maintained hemodynamic stability and no major airway events were reported.
Conclusions: The RISE registry data suggest that desflurane-based anesthesia provides early recovery with stable hemodynamics without any airway adverse events, in a wide variety of surgical procedures.