Users Online: 4006 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  
Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 


RSACP wishes to inform that it shall be discontinuing the dispatch of print copy of JOACP to it's Life members. The print copy of JOACP will be posted only to those life members who send us a written confirmation for continuation of print copy.
Kindly email your affirmation for print copies to dranjugrewal@gmail.com preferably by 30th June 2019.

 

 
Table of Contents
LETTER TO EDITOR
Year : 2018  |  Volume : 34  |  Issue : 2  |  Page : 271-273

Intraoperative baroreflex failure following lignocaine infiltration during unilateral radical neck dissection


Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India

Date of Web Publication16-Jul-2018

Correspondence Address:
Smita Prakash
C 17 HUDCO Place, New Delhi - 110 049
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9185.173380

Rights and Permissions

How to cite this article:
Prakash S, Kale S, Talwar V, Pawar M. Intraoperative baroreflex failure following lignocaine infiltration during unilateral radical neck dissection. J Anaesthesiol Clin Pharmacol 2018;34:271-3

How to cite this URL:
Prakash S, Kale S, Talwar V, Pawar M. Intraoperative baroreflex failure following lignocaine infiltration during unilateral radical neck dissection. J Anaesthesiol Clin Pharmacol [serial online] 2018 [cited 2019 Nov 15];34:271-3. Available from: http://www.joacp.org/text.asp?2018/34/2/271/173380



Madam,

The baroreceptor reflex serves to prevent excessive fluctuations of arterial blood pressure (BP). In baroreflex failure, there is loss of buffering ability and wide excursions of pressure and heart rate (HR) occur.[1] We report a 58-year-old patient who developed intraoperative baroreflex failure manifesting as severe hypotension necessitating vasopressor support following lignocaine infiltration in the carotid sinus area during unilateral radical neck dissection (RND).

A 58-year-old male, with neck secondaries, was scheduled for left RND. Baseline hemodynamic parameters were normal. Anesthesia was induced with morphine 4.5 mg and propofol 90 mg. Intubation was facilitated with atracurium 30 mg. Marked hemodynamic lability was observed at induction and intubation [Table 1]. Anesthesia was maintained with 0.6% isoflurane in N2O and O2. The initial intraoperative period was associated with bradycardia, followed by tachycardia and hypertension [Table 2]. Anesthesia was deepened (isoflurane 1-2%, fentanyl 50 μg) and esmolol 20 mg intravenous (IV) was administered. As tachycardia persisted, the operative site near carotid bifurcation was infiltrated with 5 ml lignocaine 2% (without preservative). The hemodynamic perturbations that followed lignocaine infiltration and its management are detailed in [Table 2]. The patient received IV boluses of mephentermine and adrenaline. Dopamine infusion was initiated (15 μg/kg/min) followed by norepinephrine infusion (5 μg/min). Within 2 min of norepinephrine infusion, BP stabilized between 110/87/91 and 117/74/91 mmHg; however, tachycardia persisted (HR 155-172/min). Isoflurane was re-started, FiO2 was 0.5 and esmolol 20 mg IV was administered. Arterial blood gas (ABG) analysis revealed metabolic acidosis. Surgery recommenced. Dopamine and norepinephrine infusion rates were reduced. At 75 min of lignocaine infiltration, norepinephrine was discontinued, and dopamine continued at 5 μg/kg/min. HR was 100/min, BP 103/65/79 mmHg, SpO2100% with FiO20.5. Left RND was completed. Patient received 2.5 L Ringer's lactate solution. The patient was transferred to the Intensive Care Unit on controlled ventilation. Echocardiogram was normal. Two hours after lignocaine infiltration, the patient was hemodynamically stable, ABG was normal, dopamine infusion was discontinued and trachea was extubated. The patient had a normal recovery.
Table 1: HR and BP changes during induction of anesthesia and intubation

Click here to view
Table 2: Summary of intraoperative events during left radical neck dissection

Click here to view


During RND, surgical manipulation around the carotid artery has the potential to cause hemodynamic perturbations and dysrhythmias. Our 58-year-old, normotensive patient developed tachycardia and hypertension intraoperatively during unilateral RND. The hemodynamic changes did not respond to conventional methods. Local anesthetic (LA) infiltration near the carotid bifurcation was performed with the intention of mitigating tachycardia and hypertension. We had not anticipated the occurrence of severe hypotension that followed LA infiltration. The response to norepinephrine suggests that the patient experienced severe vasomotor failure. A search of the literature revealed some interesting data.

Baroreflex failure is likely to develop in patients after RND,[2] carotid artery surgery, throat irradiation and neck injury.[1] The baroreceptors are located in the carotid sinus at the bifurcation of the common carotid artery and in the aortic arch. For clinical baroreflex failure to manifest, severe interruption of afferent input must be present. We believe that the occurrence of severe hypotension following LA infiltration in the carotid sinus area was a consequence of baroreflex failure.

Manipulation of these baroreceptors during neck surgery may result in bradycardia, hypotension or cardiac dysrhythmia.[3] Many surgeons advocate anesthetizing the carotid bulb prophylactically; however, this practice is not universally accepted. LA infiltration of the carotid sinus may result in hypertension,[4] hypotension [5],[6] or no effect.[7] Barman et al.[4] reported possibly harmful intraoperative increases in systolic BPs and mean pressures with lidocaine infiltration of the carotid sinus. Tang et al.[5] found that LA blockade of the carotid sinus was associated with a pooled odds ratio of hypotension −1.25 (95% confidence interval [CI] 0.496-3.15; P = 0.216) and hypertension −1.28 (95% CI 0.699-2.33; P = 0.428) for development of postoperative hypotension and hypertension, respectively. Although none reached significance, there was a trend toward increased risk of developing a complication in those patients who received LA. Similarly, stripping the aortic arch and the carotid sinus areas (sino-aortic denervation) in dogs resulted in extreme lability of arterial BP with normal, hypertensive and hypotensive values being recorded.[6]

Carotid sinus hypersensitivity (CSH), an exaggerated response of the carotid sinus baroreceptor to local stimulation, is a possibility in our patient that manifested intraoperatively as baroreflex failure following LA infiltration. The exhibition of BP lability during induction of anesthesia and intubation, intraoperative occurrence of severe bradycardia initially and later tachycardia with hypertension during RND suggests the presence of CSH in our patient. The incidence of intraoperative CSH is 28% in elderly patients undergoing RND.[8] Local factors that exert pressure on the carotid sinus such as tumor, lymph nodes, and scars may lead to CSH.[3] The majority of reports of carotids sinus syndrome associated with head and neck malignancy relate to extensive nodal involvement in the neck;[9] our patient had nodal neck secondaries. The temporal sequence of hemodynamic events following LA infiltration around the carotid bifurcation (in a bid to control the hemodynamic response during RND), the response to norepinephrine and the subsequent return of hemodynamics to ≈ 90-100 mmHg at 75 min is in keeping with duration of action of lignocaine and suggests that baroreflex failure was a consequence of lignocaine infiltration. Clinicians should be aware of the possibility of occurrence of hemodynamic lability should they consider LA infiltration in the carotid sinus area during RND.



 
  References Top

1.
Ketch T, Biaggioni I, Robertson R, Robertson D. Four faces of baroreflex failure: Hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia. Circulation 2002;105:2518-23.  Back to cited text no. 1
    
2.
Prakash S, Rapsang A, Kumar SS, Bhatia PS, Gogia AR. Postoperative hypertension following radical neck dissection. J Anaesthesiol Clin Pharmacol 2012;28:121-3.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Babin RW, Panje WR. The incidence of vasovagal reflex activity during radical neck ddissection. Laryngoscope 1980;90:1321-3.  Back to cited text no. 3
    
4.
Barman AA, Moideen AS, Chaudhry SS, Ardell J, Barman SA, Cantu R. Nerve-sparing dissection as alternative to anesthesia of carotid sinus nerve in preparation for carotid endarterectomy. Tex Heart Inst J 1989;16:107-9.  Back to cited text no. 4
    
5.
Tang TY, Walsh SR, Gillard JH, Varty K, Boyle JR, Gaunt ME. Carotid sinus nerve blockade to reduce blood pressure instability following carotid endarterectomy: A systematic review and meta-analysis. Eur J Vasc Endovasc Surg 2007;34:304-11.  Back to cited text no. 5
    
6.
Cowley AW Jr, Liard JF, Guyton AC. Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res 1973;32:564-76.  Back to cited text no. 6
    
7.
Ajduk M, Tudoric I, Sarlija M, Pavic P, Oremuš Z, Held R, et al. Effect of carotid sinus nerve blockade on hemodynamic stability during carotid endarterectomy under local anesthesia. J Vasc Surg 2011;54:386-93.  Back to cited text no. 7
    
8.
Kim TI, Lim HJ, Chang SH, Kim NS. Intraoperative carotid sinus hypersensitivity and postoperative complication of radical neck dissection retrospective study. Korean J Crit Care Med 1998;13:49-54.  Back to cited text no. 8
    
9.
Papay FA, Roberts JK, Wegryn TL, Gordon T, Levine HL. Evaluation of syncope from head and neck cancer. Laryngoscope 1989;99:382-8.  Back to cited text no. 9
    



 
 
    Tables

  [Table 1], [Table 2]



 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
   References
   Article Tables

 Article Access Statistics
    Viewed1180    
    Printed118    
    Emailed0    
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal