Journal of Anaesthesiology Clinical Pharmacology

EDITORIAL
Year
: 2011  |  Volume : 27  |  Issue : 3  |  Page : 303--306

Fospropofol: Is there an infusion regimen for propofol equivalence?


Glen Atlas 
 Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark; Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA

Correspondence Address:
Glen Atlas
Department of Anesthesiology University of Medicine and Dentistry of New Jersey 185 S. Orange Ave. MSB E-538 Newark, NJ 07103
USA




How to cite this article:
Atlas G. Fospropofol: Is there an infusion regimen for propofol equivalence?.J Anaesthesiol Clin Pharmacol 2011;27:303-306


How to cite this URL:
Atlas G. Fospropofol: Is there an infusion regimen for propofol equivalence?. J Anaesthesiol Clin Pharmacol [serial online] 2011 [cited 2019 Sep 17 ];27:303-306
Available from: http://www.joacp.org/text.asp?2011/27/3/303/83671


Full Text

Propofol is an intravenous (IV) sedative hypnotic which is commonly used as a bolus for the induction of general anesthesia. It is also used as an infusion for continuous sedation and as an adjunct for general anesthesia. The main advantage of propofol, as compared with other IV sedatives, is that it has an ultra-short half-life. This allows for a relatively rapid awakening. [1],[2] Furthermore, propofol is devoid of the side effects of both nausea and vomiting. In addition, continuous low-dose infusions have been successfully utilized to treat recalcitrant nausea. [3]

Fospropofol is a water-soluble prodrug of propofol. [4],[5] These two features give fospropofol clinical advantages, as well as disadvantages, with respect to propofol. Specifically, its water solubility allows it to be manufactured without egg lecithin, soy bean extract, or glycerol. Note that these are used as diluents with propofol. Furthermore, these additional ingredients may support microbial growth despite the presence of antimicrobial preservatives. [6],[7],[8] Moreover, administration of propofol to patients allergic to any of these additives is contraindicated. Hypertriglyceridemia, presumably from these diluents, has also been reported. [9],[10] Of note, a lipid-free propofol formulation is currently being developed and investigated. [11]

Additionally, the current preparation of propofol produces pain on injection. This frequently requires the concomitant use of such medications as lidocaine, or ketamine, as analgesics. [12],[13],[14],[15] It should be noted that ketamine has both local and general anesthetic properties.

In addition, propofol is lipophilic and is prepared as an emulsion. Thus, prolonged storage can lead to separation or "cracking" of the emulsion. [16],[17] Propofol is also difficult to manufacture and numerous recalls, as well as shortages, of this drug have occurred. [18]

As shown in [Figure 1], propofol is based upon phenol, with the addition of two isopropyl side chains, which are located at positions 2 and 6.{Figure 1}

However, fospropofol, as shown in [Figure 2], is a water-soluble salt which utilizes phosphate and sodium ions.{Figure 2}

Since fospropofol is a prodrug, a delay in peak onset occurs following the administration of a single dose. Using a 10 mg/ kg IV bolus, the median time to sedation was reported as approximately 7 minutes with a range of 1 to 15 minutes. [4] This is in contradistinction to propofol which has a near-immediate effect. [2] Because of this, propofol is frequently used for rapid-sequence induction of general anesthesia, whereas this would not be possible with fospropofol. Furthermore, the time to awakening with fospropofol was reported within a range of 21 to 45 minutes; although still short, this is significantly longer than propofol. [4] Somewhat similar dose-response and pharmacodynamic properties have been reported in other clinical studies. [19],[20] In addition, the major side effects of fospropofol are pruritus as well as paresthesias. These are transient. [4],[18],[19],[20],[21]

Alkaline phosphatases enzymatically degrade fospropofol to propofol, with formaldehyde, formate, and phosphate produced as metabolic byproducts. [4] These are illustrated in [Figure 3]. Of note, formate is the anion of formic acid which is responsible for the itching produced from insect venom. This may explain fospropofol's side effect of pruritus. However, the resultant blood formaldehyde levels are not considered clinically significant.{Figure 3}

Currently, fospropofol is only administered in intermittent IV boluses. However, a continuous infusion of this drug would result in a more stable level of sedation. Furthermore, the potential for excessive propofol levels from an IV bolus may be reduced with a carefully administered continuous infusion. Lastly, the use of syringe pumps, or other similar technology, would be more convenient than repetitive bolus administration.

To accomplish this, a "target dose" of propofol from the administration of fospropofol would need to be determined. This would result from a "propofol equivalent" regimen of fospropofol dosing. An understanding of the gram-molar relationship between fospropofol and propofol is therefore necessary. Explicitly, one mole of fospropofol produces one mole of propofol. [4] This is in contradistinction to an "approximate milligram equivalence" which is typically used when comparing similar-acting medications. Furthermore, equimolar dosing is frequently utilized when establishing bioequivalence. [22]

Thus, the number of moles for a given amount of drug is a direct representation of its associated number of molecules. To further illustrate the concept of equimolar dosing, the number of moles of propofol produced from an infusion of 100 mg/(kg·min), is: [23]

[INLINE:1]

Note that the molecular weight of propofol is 178.27 g/ mole. However, the molecular weight of fospropofol is 332.24 g/ mole. Based upon the molar dose from equation (1), the dose of fospropofol to produce an equimolar amount of propofol is as follows:

[INLINE:2]

Thus, in terms of producing an equivalent number of moles of propofol:



[INLINE:3]

Furthermore, the above ratio in equation (3) remains valid for other "target dosages" of propofol which would be produced from an infusion of fospropofol:



[INLINE:4]

It should also be noted that fospropofol is manufactured in a more concentrated form than propofol. Specifically, fospropofol has a concentration of 35 mg/ml, whereas the concentration of propofol is 10 mg/ml. Thus, the net flow rate for a fospropofol infusion is significantly less than that of an equimolar propofol infusion. This occurs despite the greater molecular weight of fospropofol.

As an example, for a propofol dose of 100 mg/(kg·min), the net flow rate, per kg body weight, is:

[INLINE:5]

However, the flow rate per kg body weight for an equimolar dose of fospropofol is:

[INLINE:6]

Further research is necessary to clinically evaluate the benefits and limitations of a "propofol equivalent" dosing regimen of a continuous infusion of fospropofol. This would include blood levels of propofol, formaldehyde, phosphate, and formate which are produced from the metabolism of fospropofol.

 Appendix: Numerical Examples



Example 1. It is desired to administer fospropofol based upon a molar equivalent of 90[INSIDE:1] of propofol. Using Equation (4):



[INLINE:7]

Based upon Equation (6), the associated flow rate per kg would be:

[INLINE:8]

For a 70 kg patient, this would correspond to a flow rate of:

[INLINE:9]

Example 2. It is desired to administer fospropofol using the molar equivalent of a propofol dose of 120[INSIDE:2]120. This would correspond to:

[INLINE:10]

Based upon Equation (6), the associated flow rate per kg would be:

[INLINE:11]

For a 70 kg patient, this would correspond to a flow rate of:

[INLINE:12]

References

1Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB, Shafer SL, et al. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology 1998;88:1170-82.
2Schuttler J, Ihmsen H. Population pharmacokinetics of propofol: A multicenter study. Anesthesiology 2000;92:727-38.
3Kim SI, Han TH, Kil HY, Lee JS, Kim SC. Prevention of postoperative nausea and vomiting by continuous infusion of subhypnotic propofol in female patients receiving intravenous patient-controlled analgesia. Br J Anaesth 2000;85:898-900.
4Lusedra© (fospropofol disodium) package insert.Fospropofol prescribing information. Woodcliff Lake, NJ, USA: Eisai corp;2009.
5Bengalorkar GM, Bhuvana K, Sarala N, Kumar, TN. Fospropofol: Clinical pharmacology. J Anaesth Clin Pharmacol 2011;27:79-83.
6Kuehnert MJ, Webb RM, Jochimsen EM, Hancock GA, Arduino MJ, Hand S, et al. Staphylococcus aureus bloodstream infections among patients undergoing electroconvulsive therapy traced to breaks in infection control and possible extrinsic contamination by propofol.Anesth Analg 1997;85:420-5.
7Wachowski I, Jolly DT, Hrazdil J, Galbraith JC, Greacen M, Clanachan AS. The growth of microorganisms in propofol and mixtures of propofol and lidocaine. Anesth Analg 1999;88:209-12.
8Shimizu K, Hirose M, Mikami S, Takamura K, Goi T, Yamaguchi A, et al. Effect of anaesthesia maintained with sevoflurane and propofol on surgical site infection after elective open gastrointestinal surgery. J Hosp Infect 2010;74:129-36.
9Knibbe CA, Naber H, Aarts LP, Kuks PF, Danhof M. Long-term sedation with propofol 60 mg/ml vs. propofol 10 mg/ml in critically ill, mechanically ventilated patients. Acta Anaesthesiol Scand 2004;48:302-7.
10Coetzee A, Blaine EM, Labadarios D, Schall R, Haus M. Effect of 1% and 2% propofol on blood lipids during long-term sedation. S Afr Med J 2002;92:911-6.
11Mohite SN, Kudalkar AG, Dalvi NP. A comparative study of premixed lipid-free propofol and lignocaine vs lipid emulsion of propofol in conscious sedation. J Anaesth Clin Pharmacol 2010;26:303-6.
12Lee P, Russell WJ. Preventing pain on injection of propofol: A comparison between lignocaine pre-treatment and lignocaine added to propofol. Anaesth Intensive Care 2004;32:482-4.
13Tan CH, Onsiong MK, Kua SW. The effect of ketamine pretreatment on propofol injection pain in 100 women. Anaesthesia 1998;53:302-5.
14Wagner LE 2nd, Gingrich KJ, Kulli JC, Yang J. Ketamine blockade of voltage-gated sodium channels: Evidence for a shared receptor site with local anesthetics. Anesthesiology 2001;95:1406-13.
15Tverskoy M, Oren M, Vaskovich M, Dashkovsky I, Kissin I. Ketamine enhances local anesthetic and analgesic effects of bupivacaine by peripheral mechanism: A study in postoperative patients. Neurosci Lett 1996;215:5-8.
16Han J, Davis SS, Washington C. Physical properties and stability of two emulsion formulations of propofol. Int J Pharm 2001;215:207-20.
17Chernin EL, Smiler B. Any propofol compatibility study must include an emulsion stability analysis. Anesth Analg 2000;91:1307-8.
18Jensen V, Rappaport BA. The reality of drug shortages - the case of the injectable agent propofol. N Engl J Med 2010;363:806-7.
19Gan TJ, Berry BD, Ekman EF, Muckerman RC 2 nd , Shore N, Hardi R. Safety evaluation of fospropofol for sedation during minor surgical procedures.J Clin Anesth 2010;22:260-7.
20Cohen LB. Clinical trial: A dose-response study of fospropofol disodium for moderate sedation during colonoscopy.Aliment Pharmacol Ther 2008;27:597-608.
21Garnock-Jones KP, Scott LJ. Fospropofol. Drugs 2010;70:464-77.
22Birkett DJ. Generics-equal or not? Aust Prescr 2003;26:85-7.
23Amiji MM, Sandmann BJ, editors. Applied physical pharmacy. New York: McGraw-Hill; 2003.