Journal of Anaesthesiology Clinical Pharmacology

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 28  |  Issue : 4  |  Page : 456--459

A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy


Mausumi Neogi1, Santanu Basak1, Debasis Ghosh1, Sandip Mukherjee1, Satrajit Dawn2, Dhurjoti P Bhattacharjee2 
1 Department of Anaesthesiology, Burdwan Medical College, Burdwan, West Bengal, India
2 Department of Anaesthesiology, Calcutta National Medical College, Kolkata, West Bengal, India

Correspondence Address:
Mausumi Neogi
41, Hrishi Bankim Street, Konnagar, Hoogly, West Bengal
India

Background: Carbon dioxide pneumoperitoneum for laparoscopic surgery increases arterial pressures, heart rate, and systemic vascular resistance. In this randomized double-blind placebo-controlled clinical study, we investigated the efficacy of gabapentin premedication to provide perioperative hemodynamic stability in patients undergoing laparoscopic cholecystectomy. Materials and Methods: Sixty patients, of either sex (18-65 years of age) undergoing elective laparoscopic cholecystectomy were randomly allocated to two groups of 30 patients each. Patients of group G received oral gabapentin 900 mg 2 h before induction of anesthesia, while patients in group P received placebo at the same time. Results: Mean arterial pressure in patients of group G were significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, as compared to group P, throughout the pneumoperitoneum. Similarly, heart rate in group G was significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, in comparison to group P, throughout the peumoperitoneum. Intravenous labetalol was required, to control intraoperative hypertension, in 33.3% (10 out of 30) patients in group P. There was no significant difference in the incidence of adverse effects between the two groups. Conclusion: Gabapentin premedication provided perioperative hemodynamic stability during laparoscopic surgery.


How to cite this article:
Neogi M, Basak S, Ghosh D, Mukherjee S, Dawn S, Bhattacharjee DP. A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy.J Anaesthesiol Clin Pharmacol 2012;28:456-459


How to cite this URL:
Neogi M, Basak S, Ghosh D, Mukherjee S, Dawn S, Bhattacharjee DP. A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy. J Anaesthesiol Clin Pharmacol [serial online] 2012 [cited 2020 Aug 3 ];28:456-459
Available from: http://www.joacp.org/article.asp?issn=0970-9185;year=2012;volume=28;issue=4;spage=456;epage=459;aulast=Neogi;type=0