Journal of Anaesthesiology Clinical Pharmacology

CASE REPORT
Year
: 2020  |  Volume : 36  |  Issue : 2  |  Page : 265--267

Continuous stellate ganglion block in delayed cerebral ischemia: A possible supplementary approach to traditional therapy?


Andrea Bortolato1, Davide Simonato2, Paolo Feltracco1, Marina Munari3,  
1 Institute of Anesthesia and Intensive Care Medicine, University Hospital of Padova, Padova, Italy
2 Institute of Radiology, University Hospital of Padova, Padova, Italy
3 Neuroanesthesia and Intensive Care Unit, University Hospital of Padova, Padova, Italy

Correspondence Address:
Dr. Andrea Bortolato
Anesthesia and Intensive Care University-Hospital of Padua, Via Nicolò Giustiniani n. 2, 35121 Padova
Italy

Abstract

Delayed Cerebral Ischemia (DCI) is a major contributor to morbidity and mortality after SAH. Currently the prevention of vasospasm and DCI relies on nimodipine administration and on maintaining an adequate cerebral perfusion pressure. We report a patient with initial DCI after SAH in which stellate ganglion block (SGB) was performed after nimodipine administration. Firstly the procedure was characterized by a iv and intra-arterial nimodipine administration which did not result into a normal perfusion pattern. Therefore a single-shot stellate ganglion block was performed, as suggested in literature. Because of the not sufficient but promising perfusion improvement, we decided to deliver a continuous ganglion block (cSGB) for 5 days. Consequently a further improvement of the cerebral perfusion on CTPerfusion and Real Time Angiographic Perfusion Assessment was registered. In order to treat cerebral vasospasm, SGB is known to be a further valuable treatment, despite its temporary effect. However the continuous use of SGB during initial DCI has never been described before.



How to cite this article:
Bortolato A, Simonato D, Feltracco P, Munari M. Continuous stellate ganglion block in delayed cerebral ischemia: A possible supplementary approach to traditional therapy?.J Anaesthesiol Clin Pharmacol 2020;36:265-267


How to cite this URL:
Bortolato A, Simonato D, Feltracco P, Munari M. Continuous stellate ganglion block in delayed cerebral ischemia: A possible supplementary approach to traditional therapy?. J Anaesthesiol Clin Pharmacol [serial online] 2020 [cited 2020 Aug 14 ];36:265-267
Available from: http://www.joacp.org/text.asp?2020/36/2/265/286776


Full Text



Delayed cerebral ischemia (DCI) is the major cause of morbidity and mortality in a patient with subarachnoid hemorrhage (SAH). The stellate ganglion block (SGB) has been proposed as an effective rescue treatment of this unfavorable complication. The rationale of the application of SGB relies on the fact that pial vessels are densely supplied with noradrenergic sympathetic nerve fibers, which originate from the superior cervical ganglion, accompanying the carotid artery, and project to the ipsilateral hemisphere.[1],[2] Consequently, cerebral arteries constrict in response to cervical sympathetic stimulation and dilate when sympathetic nerve fibers are damaged or blocked.[3],[4]

Herein, we report a patient with SAH-related DCI treated successfully, first with intravenous (IV) and intra-arterial nimodipine aided by a single shot SGB, and then with a continuous SGB (cSGB).

A 60-year-old woman was admitted to the emergency department for tachypnea, headache, and impaired level of consciousness (Glasgow Coma Scale [GCS]) =11; Hunt and Hess Scale = 3, blood pressure =150/80, heart rate [HR] in the range of 60–70 bpm). A computed tomography (CT) scan of the head and CT angiography revealed SAH (modified Fisher-scale IV) because of a berry-like ruptured anterior-communicating artery aneurysm.

First, the patient underwent endovascular aneurysm repair with coils, and then a left fronto-parietal decompressive craniotomy to decrease the intracranial pressure (ICP). IV nimodipine therapy (2 mg/hi.v.) was administered under the strict control of hemodynamic monitoring for the prevention of cerebral vasospasm.

On day 13, the patient's symptoms worsened, with fever, tachycardia, a reduction from 9 to 4 of GCS, a severe increase in serum C reactive protein (240 mg/L), and no changes of procalcitonin level. Marked changes of C Reactive Protein are considered by some authors as a sensitive marker of cerebral vasospasm,[5] and are evaluated by our center in this setting. A diagnostic suspicion of cerebral vasospasm required an emergent CT perfusion that showed under-perfusion of some areas in frontal lobes. There was a distal narrowing of the right anterior and middle cerebral artery branches on CT-angiography (CTA), and these findings were also confirmed by digital subtraction angiography. Therefore, an intra-arterial bolus of 3 mg nimodipine was injected into the right internal carotid artery. A two-dimensional (2D)-perfusion-analysis (Allura Clarity, Philips Healthcare, Best, Netherlands) was also performed to evaluate the possible changes of the cerebral blood flow parameters after the bolus. Despite nimodipine bolus, the mean transit time was found to be still high (4.5 sec) in the watershed territories between the right anterior and middle cerebral arteries.[6] Hence to manage vasospasm and to improve the cerebral perfusion a right-sided SGB was administered using 20 ml bolus of ropivacaine 0.5% injected at C7- T1 level through a 24-gauge fluoroscopically guided needle via anterior paratracheal approach. The injection of a relatively high volume (20 ml) of a highly concentrated anesthetic solution (0.5%) was preferred to both improve the spread of anesthetic solution to cervical and thoracic ganglia and prolong the effect of single shot block.

Fifteen minutes after the block, the 2D-perfusion-analysis revealed an improvement of the mean transit time from 4.5 sec to 3.0 sec [Figure 1]. Considering that the SGB was supposed to last a maximum of 20–24 h, we decided to implement a continuous SGB, with the purpose to prevent the continuous activation of sympathetic nerve fibers. A right perineural catheter was placed with the aid of ultrasound and fluoroscopy (Pajunk Medizintechnologie, Geisingen, Germany), maintaining the same site of access to the SGB [Figure 2]. The 48-h CT-perfusion imaging revealed a normal perfusion pattern with no further ischemic areas and a CTA showed normal cerebral blood flow. Continuous infusion of ropivacaine 0,2% at 5 ml/h was released for five days, till the time inflammatory markers normalized.{Figure 1}{Figure 2}

The patient was therefore discharged, with GCS of 10 and right hemiplegia. At a 12-months follow-up visit, only moderate disability was assessed (modified Rankin Scale = 3).

SGB decreases cerebral blood flow velocity, which in turn improves cerebral blood flow and perfusion thereby improving the clinical neurological signs. Moreover, SGB may produce a significant decrease in zero flow pressure, which is an indirect marker of cerebral vascular tone,[7] as well as providing an improvement of regional cerebral oxygenation.[8]

As a result, encouraging effect on perfusion by SGB prompted us to try to guarantee this effect over the 24 hours with a continuous peri nervous stellate block, thus avoiding the complications of repeated angiography or the positioning of an intra-arterial microcatheter for continuous nimodipine infusion.[9] Complications are rare but can be life-threatening. The incidence of severe complications was 1.7 in 1000 blockades after performance of 45,000 SGBs, and most of these were neurological complications (i.e., convulsions). A high subarachnoid block was reported in six cases, high epidural blockade in three, pneumothorax in nine, and allergic reactions in two.[10]

Eventually, whenever invasive medical approaches fail or are temporarily inapplicable SGB may be considered as a rescue modality in the setting of DCI.[3]

Informed consent

Informed consent was obtained from the individual participant included in the study.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that her name and initials will not be published and due efforts will be made to conceal her identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

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