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  Indian J Med Microbiol
 

Figure 1: Metabolic pathways impacted by statins and proprotein convertase subtilisin/kexin Type 9 inhibitors. Decreased cholesterol synthesis results in upregulation of low-density lipoprotein cholesterol receptors and greater clearance of low-density lipoprotein cholesterol. When proprotein convertase subtilisin/kexin Type 9 is bound to the low-density lipoprotein cholesterol receptor, the internalized receptor is more likely to be degraded. With lower proprotein convertase subtilisin/kexin Type 9 activity due to proprotein convertase subtilisin/kexin Type 9 inhibitors, low-density lipoprotein receptors are more likely to be recycled to the cell surface to clear plasma low-density lipoprotein cholesterol. VLDL = Very low-density lipoprotein, TG = Triglyceride, ApoB = Apolipoprotein B. By permission of Mayo Foundation for Medical Education and Research

Figure 1: Metabolic pathways impacted by statins and proprotein convertase subtilisin/kexin Type 9 inhibitors. Decreased cholesterol synthesis results in upregulation of low-density lipoprotein cholesterol receptors and greater clearance of low-density lipoprotein cholesterol. When proprotein convertase subtilisin/kexin Type 9 is bound to the low-density lipoprotein cholesterol receptor, the internalized receptor is more likely to be degraded. With lower proprotein convertase subtilisin/kexin Type 9 activity due to proprotein convertase subtilisin/kexin Type 9 inhibitors, low-density lipoprotein receptors are more likely to be recycled to the cell surface to clear plasma low-density lipoprotein cholesterol. VLDL = Very low-density lipoprotein, TG = Triglyceride, ApoB = Apolipoprotein B. By permission of Mayo Foundation for Medical Education and Research