| ORIGINAL ARTICLE |
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| Year : 2012 | Volume
: 28
| Issue : 4 | Page : 456-459 |
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A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy
Mausumi Neogi1, Santanu Basak1, Debasis Ghosh1, Sandip Mukherjee1, Satrajit Dawn2, Dhurjoti P Bhattacharjee2
1 Department of Anaesthesiology, Burdwan Medical College, Burdwan, West Bengal, India
2 Department of Anaesthesiology, Calcutta National Medical College, Kolkata, West Bengal, India
Correspondence Address:
Mausumi Neogi
41, Hrishi Bankim Street, Konnagar, Hoogly, West Bengal
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-9185.101903
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Background: Carbon dioxide pneumoperitoneum for laparoscopic surgery increases arterial pressures, heart rate, and systemic vascular resistance. In this randomized double-blind placebo-controlled clinical study, we investigated the efficacy of gabapentin premedication to provide perioperative hemodynamic stability in patients undergoing laparoscopic cholecystectomy.
Materials and Methods: Sixty patients, of either sex (18-65 years of age) undergoing elective laparoscopic cholecystectomy were randomly allocated to two groups of 30 patients each. Patients of group G received oral gabapentin 900 mg 2 h before induction of anesthesia, while patients in group P received placebo at the same time.
Results: Mean arterial pressure in patients of group G were significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, as compared to group P, throughout the pneumoperitoneum. Similarly, heart rate in group G was significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, in comparison to group P, throughout the peumoperitoneum. Intravenous labetalol was required, to control intraoperative hypertension, in 33.3% (10 out of 30) patients in group P. There was no significant difference in the incidence of adverse effects between the two groups.
Conclusion: Gabapentin premedication provided perioperative hemodynamic stability during laparoscopic surgery. |
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