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Year : 2012  |  Volume : 28  |  Issue : 4  |  Page : 505-507

Quinine-induced bronchiolitis obliterans and organizing pneumonia

1 Department of Intensive Care, Tawam Hospital in Affiliation with Johns Hopkins Medicine, Al Ain, United Arab Emirates
2 Department of Medicine, Tawam Hospital in Affiliation with Johns Hopkins Medicine, Al Ain, United Arab Emirates

Correspondence Address:
Said Abuhasna
Department of Critical Care Medicine, Tawam Hospital, Al Ain
United Arab Emirates
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9185.101942

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Quinine is a vital anti-malarial drug used in the management of resistant Falciparum malaria. There are previous reports of quinine-induced pulmonary edema and infiltrates. We report the first case of biopsy-proven bronchiolitis obliterans organizing pneumonia (BOOP), confirmed by the Naranjo Adverse Drug Reaction Probability Scale (NADRS) of 5 and a severity scale of 5, secondary to intravenous quinine, in a 15-year-old girl with Plasmodium falciparum infection after a visit to Kenya. Clinical course of the patient followed by review of the literature and appropriate medical interventions for quinine-induced BOOP are suggested.

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