Users Online: 984 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  
Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 

RSACP wishes to inform that it shall be discontinuing the dispatch of print copy of JOACP to it's Life members. The print copy of JOACP will be posted only to those life members who send us a written confirmation for continuation of print copy.
Kindly email your affirmation for print copies to [email protected] preferably by 30th June 2019.


Table of Contents
Year : 2014  |  Volume : 30  |  Issue : 3  |  Page : 433-434

Anesthesia in a patient with multiple allergies

Department of Anaesthesia, Mahatma Gandhi Mission's Medical College and Hospital, Aurangabad, Maharashtra, India

Date of Web Publication22-Jul-2014

Correspondence Address:
Sanhita J Kulkarni
50, Aditya Nagar, Gerkheda, Aurangabad - 431 009, Maharashtra
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9185.137291

Rights and Permissions

How to cite this article:
Kulkarni SJ, Kelkar VP, Nayak PP. Anesthesia in a patient with multiple allergies. J Anaesthesiol Clin Pharmacol 2014;30:433-4

How to cite this URL:
Kulkarni SJ, Kelkar VP, Nayak PP. Anesthesia in a patient with multiple allergies. J Anaesthesiol Clin Pharmacol [serial online] 2014 [cited 2021 Jun 19];30:433-4. Available from:


Prevalence of drug allergies shows wide variability from 10% to 40% in various studies. [1] It is reported to be 0.2% to 28% in Indian population. [2] We report successful anesthetic management of a patient having multiple drug allergies.

A 56 year old female patient was admitted with the complaint of pain in the abdomen. Investigations revealed cholelithiasis. Laparoscopic (lap.) cholecystectomy was planned. Since 15-20 years, she had generalized urticaria with itching off and on with occasional severe breathlessness requiring hospitalization and had under gone in vitro allergy testing by the enzyme immunosorbent assay. Besides some food substances, she was also allergic to Ciprofloxacin, Amoxicillin, Ofloxacin, Diclofenac, Paracetamol, but not to Ibuprofen, Epinephrine, Lignocaine, Theophylline, Alcohol, Iodine and Latex.

Preoperative vital parameters, blood investigations, electrocardiogram and chest X- ray were normal. Intradermal allergic testing of the anesthetic agents to be used was performed. She was allergic to Vecuronium, but was non allergic to Thiopentone, Fentanyl, Ondansetron, and Atropine. Therefore surgery was planned under epidural anesthesia.

Thoracic epidural catheter was inserted in lateral position in T 8-9 space. A total volume of 12 ml of 2% preservative free lignocaine with 50 mcg adrenaline and 25 mcg fentanyl was injected. Sensory block from T4 to L1 was achieved after 15 min. Intra operative hemodynamics remained stable. Postoperative analgesia was given using fentanyl patch and Tablet Ibuprofen. Patient was discharged uneventfully after 48 h.

Drug allergies, being one of the causes of catastrophic events occurring in the Peri-operative period, are of major concern to anesthesiologists. Although intraoperative drug anaphylaxis is rare, it contributes to 4.3% of deaths occurring during general anesthesia. [1]

Life-threatening hypersensitivity reactions are more likely to occur in patients with a history of allergy, atopy or asthma. Hence in a patient giving history of multiple drug allergies, an allergological assessment should be performed prior to surgical procedure.

Skin scratch test should precede an intradermal test in high risk patients, since the latter has a higher risk of causing anaphylaxis. Antihistaminics and corticosteroids are stopped 1 week prior to the skin testing .[1]

The incidence of allergies to the commonly used drugs in the perioperative period is shown in [Table 1]. [1],[3],[4]
Table 1: Incidence of allergies to the common peri-operative drugs

Click here to view

Cross reactivity amongst NMBAs is common. [1],[3],[4] Our patient was allergic to Vecuronium. We should have tested all NMBAs. The reason for not testing was time constraint. Each drug needed a day for testing as per the guidelines and the surgery was semi-emergency. Therefore, we decided to avoid NMBAs.

Allergy to induction agents is uncommon. [3],[4] In spite of common belief, propofol can be used in egg, soy, peanut allergic patients. [5]

There is no evidence to support the prophylactic use of antihistaminics or corticosteroids in such patients. [4]

Anesthesia of choice for lap.cholecystectomy is general anesthesia with endotracheal intubation and controlled ventilation. As we could not use muscle relaxants, we planned for epidural anesthesia. Alternative plan was inhalational induction and maintenance using O 2 , N 2 O and Sevoflurane.

Thus to conclude, patient's with multidrug allergies can undergo safe anesthesia with accurate identification of drug allergens. Avoidance of the allergens may demand a change in anesthetic plan like our choice of epidural over general anesthesia.

  References Top

1.Velickovic J, Ladjevic N, Milakovic B, Likic-Ladjevic I, Ugrinovic D, Kalezic N. Preoperative evaluation of patients with history of allergy. Acta Chir lugosl 2011;58:177-83.  Back to cited text no. 1
2.Saha A, Das NK, Hazra A, Gharami RC, Chowdhury SN, Datta PK. utaneous adverse drug reaction profile in a tertiary care out patient setting in Eastern India. Indian J Pharmacol 2012;45:792-7.  Back to cited text no. 2
3.Dewachter P, Mouton - Faivre C, Castells MC, Hepner DL. Anaesthesia in the patient with multiple drug allergies: Are all allergies the same? Current opinion in Anesthesiology 2011;24:320-5.  Back to cited text no. 3
4.Harper NJ, Dixon T, Dugue P, Edgar DM, Fay A, Gooi HC, et al. Suspected anaphylactic reactions associated with anesthesia. Anesthesia 2009;64:199-211.  Back to cited text no. 4
5.M. O'Connor. Complications of Anesthesia. In: Davies, Cashman, Editor. Lee's synopsis of anesthesia, 13 th edn. New Delhi: Elsevier Ltd; 2006. p. 357-59.  Back to cited text no. 5


  [Table 1]

This article has been cited by
1 Multiple drug allergies: Recommendations for perioperative management
Shilpadevi S. Patil,Lu Sun,Charles J. Fox,Kathryn E. Anthony,Fallon A. Anzalone,Paul M. Fisher,Brook Girma,Genkai J. Huang,Emily L. Barsley,Elyse M. Cornett,Richard D. Urman,Alan D. Kaye
Best Practice & Research Clinical Anaesthesiology. 2020;
[Pubmed] | [DOI]
2 Anaesthesia for a biopsy of corpus callosum in patient with a recent intra-operative anaphylaxis to an unknown anaesthetic allergen: a case report
Ana Licina
BMC Anesthesiology. 2018; 18(1)
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
   Article Tables

 Article Access Statistics
    PDF Downloaded323    
    Comments [Add]    
    Cited by others 2    

Recommend this journal