|Year : 2015 | Volume
| Issue : 3 | Page : 317-323
Pheochromocytoma resection: Current concepts in anesthetic management
Department of Anesthesiology, Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic, Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA
|Date of Web Publication||29-Jul-2015|
Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic, Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054
Source of Support: None, Conflict of Interest: None
Pheochromocytoma represents very significant challenges to the anesthetist, especially when undiagnosed. These chromaffin tissue tumors are not uncommon in anesthetic practice and have varied manifestations. The perioperative management of these tumors has improved remarkably over the years, in conjunction with the evolution of surgical techniques (open laparotomy to laparoscopic techniques and now to robotic approaches in the present day). This review attempts to comprehensively address the intraoperative and postoperative issues in the management of these challenging tumors with an emphasis on hemodynamic monitoring and anesthetic technique.
Keywords: Anesthetic, pharmacology, pheochromocytoma
|How to cite this article:|
Ramakrishna H. Pheochromocytoma resection: Current concepts in anesthetic management. J Anaesthesiol Clin Pharmacol 2015;31:317-23
|How to cite this URL:|
Ramakrishna H. Pheochromocytoma resection: Current concepts in anesthetic management. J Anaesthesiol Clin Pharmacol [serial online] 2015 [cited 2021 Apr 21];31:317-23. Available from: https://www.joacp.org/text.asp?2015/31/3/317/161665
| Introduction|| |
Pheochromocytomas (PCC) are rare neuroendocrine tumors originating from chromaffin tissue. In the United States, the published incidence is 2-8 diagnoses per million populations, per year.  Presently, since the only cure is surgical, these patients represent significant management problems and a high-risk of cardiovascular complications from hypertensive crises. The 2014 Endocrine Society Clinical Practice Guidelines state an overall PCC prevalence of 0.2-0.6% in patients with hypertension. In addition, they suggest that the prevalence of familial and extra adrenal tumors in patients carrying germ-line mutations in PCC susceptibility genes may be as high as 50%. 
| Perioperative Risk Assessment and Preoperative Planning|| |
Pheochromocytomas represent significant management challenges to the anesthesiologist. From a hemodynamic perspective, few other clinical situations present a more complex and life-threatening situation - particularly when undiagnosed.  The latter situation may precipitate a hypertensive crisis, which can be life-threatening, with a published 80% mortality.  Preoperative evaluation of these patients is key to successful perioperative management. Roizen et al. in 1982  proposed a set of criteria (now called the Roizen criteria) to objectively gauge the efficacy of adequate preoperative alpha blockade, and they include:
- No in-hospital blood pressure >160/90 mmHg for 24 h prior to surgery;
- No orthostatic hypotension with blood pressure <80/45 mmHg;
- No ST or T wave changes for 1-week prior to surgery;
- No more than 5 premature ventricular contractions per minute.
Over the years, these criteria have remained consistently reliable; data does exist in the literature reflecting poorer outcomes when patients have not met these criteria prior to tumor resection. His group also reported that mortality from a pheochromocytoma resection decreased from 13% to 45% before alpha blockade to 0-3% once blockade was instituted.  Most centers use some (if not all of these criteria), during the preoperative evaluation process for PCC resection, as indicators of adequate pharmacologic preparation for PCC resection. Alpha blockade has been the mainstay of preoperative preparation for pheochromocytoma patients for over 60 years  and has had a long track record of safe use. Multiple approaches to pharmacologic preparation have been proposed, however, to date, there are no randomized trials that have compared the efficacy of these varied techniques and there is no universally accepted method of preoperative blood pressure control. , In most centers, a combination of alpha-adrenergic and beta-adrenergic blockade and calcium channel blockers, in addition, are routinely used. The alpha-adrenergic blockade is typically administered starting 10-14 days preoperatively which, in addition to normalizing blood pressure, also aids in expanding the highly contracted intravascular volume - an often underappreciated issue, especially in the higher risk pheochromocytoma patients (catecholamine cardiomyopathy, myocardial infarction, and patients with refractory hypertension). Successful alpha blockade is reflected by normalizing blood pressure with mild orthostasis. Phenoxybenzamine is the drug most commonly used in the United States for alpha blockade, especially in hypertensive crises at doses ranging from 10 mg twice a day intravenous (IV) as initial dose to a total daily dose of 1 mg/kg, in hospitalized patients. Outpatients typically receive oral equivalent does of 10 mg twice a day for at least 10-14 days preoperatively, doses can be increased every 48 h. Most centers consider the presence of nasal stuffiness in conjunction with postural hypotension to be clinical indicators of adequate alpha blockade.  Other more specific short-acting and competitive alpha-1 antagonists include prazosin, terazosin, and doxazosin, which are used in doses of 2-5 mg 2 or 3 times daily for prazosin, 2-5 mg daily for terazosin, and of 2-8 mg daily for doxazosin, which can be increased to 32 mg/day. As is well known, beta blockade should never be used in isolation and only after an adequate length of alpha blockade owing to the catastrophic hypertensive crisis that would ensue with unopposed alpha receptor stimulation. , The dihydropyridine calcium channel blockers remain useful in the perioperative period as adjuncts largely because they are relatively easier to titrate and less likely to cause orthostatic hypotension.  Functioning through the inhibition of catecholamine-mediated calcium influx in vascular smooth muscle, they do not cause reflex tachycardia, lessen the severity of catecholamine-induced vasospasm, and, therefore, are particularly useful in the subset of patients with catecholamine-induced myocarditis/vasospasm. IV nicardipine has been well studied and is most widely used in the perioperative setting. ,,,
| Cardiovascular Evaluation|| |
All patients needing surgical removal of these tumors need a thorough cardiovascular evaluation. A 12-lead electrocardiogram will reveal the presence and/or extent of left ventricular strain, hypertrophy, bundle branch blocks, and ischemia. Preoperative echocardiography is essential to assess global systolic and valve function as well as to outline the severity of diastolic dysfunction that should include strain rate assessment (which essentially is an index of myocardial deformation that correlates with severity of diastolic dysfunction). Patients with longstanding tumors may develop severe dilated cardiomyopathy with varying degrees of heart failure, raising the overall perioperative risk. More routine findings in preoperative echocardiograms include moderate to severe left ventricular hypertrophy in conjunction with varying degrees of diastolic dysfunction that correlate with the severity, duration, and degree of blood pressure control. Catecholamine cardiomyopathy has been well described (catecholamine-induced cardiomyopathy)  as a form of myocardial stunning from the toxic effects of catecholamines on the myocardium. When severe, it can be associated with both cardiogenic (from severe systolic and diastolic dysfunction) and noncardiogenic pulmonary edema. The latter is modulated by the synergistic effects of cell-secreted factors on pulmonary vascular endothelium.  Another important indication for preoperative echocardiography in these patients is to rule out primary cardiac PCC in select patients. These may also be incidental findings on preoperative trans-thoracic echocardiograms. Cardiac magnetic resonance and/or computed tomography may be indicated to better delineate these masses. These are rare but have been well described in younger patients, as well as in association with multiple paraganglioma syndromes. These tumors are usually benign but tend to be locally invasive. Surgical dissection is usually impossible-given their infiltrative nature. 
| Surgical Approach|| |
Complexity of anesthetic management is largely dictated by surgical approach. Across most centers, the laparoscopic approach is preferred for most pheochromocytoma resections supported by data over the years that attests to the well-documented advantages of laparoscopic approaches in general - less postoperative pain, earlier mobilization and recovery, reduced incidence of postoperative pulmonary and thromboembolic complications, shorter hospital stays and overall cost effectiveness. ,,,
Most experienced centers perform minimally-invasive adrenalectomy via laparoscopic and retroperitoneoscopic approaches as the gold standard for a pheochromocytoma resection, particularly for adrenal masses <6 cm diameter and weight <100 g. 
Open procedures are typically reserved for larger masses and extra-adrenal tumors with limited access. Factors such as surgeon expertise, convenience, and preference are usually taken into consideration, although laparoscopic approaches should be the primary surgical technique. In addition, transperitoneal versus retroperitoneal techniques are a factor to be considered. , For patients with bilateral adrenal PCC as well as those with multiple endocrine neoplasia-2 and Von-Hippel-Lindau syndromes with unilateral masses, bilateral cortical-sparing adrenalectomy has been proposed because of the high incidence of synchronous and metachronous disease in these familial syndromes.  Given the high-risk nature of these patients, all complex pheochromocytoma resections should ideally be performed in centers that routinely perform the pheochromocytoma surgery.
| Anesthetic Goals|| |
As mentioned earlier, pheochromocytoma resection is widely considered to be among the most challenging in anesthetic practice, with the primary goal being the delivery of an anesthetic which provides stable hemodynamics in the face of catecholamine surges (especially at laryngoscopy, peritoneal insufflation, surgical stimulation, and tumor handling) followed by the opposite scenario following tumor ligation. Careful planning and meticulous technique are essential, in addition to close communication with the surgical team. The key issues are summarized below:
Relief from anxiety prior to anesthetic induction is a key component, as apprehension can predispose to catecholamine surges. Ideally, a long-acting benzodiazepine such as lorazepam or diazepam administered the night before the operation (as tolerated) in addition to a judicious dose of IV midazolam prior to transfer to the operating suite creates a calm patient less prone to hypertensive crises at induction. Invasive arterial monitoring via an intra-arterial catheter is an absolute indication in all pheochromocytoma patients prior to anesthetic induction as continuous beat-to-beat monitoring allows for close hemodynamic monitoring (and rapid pharmacologic intervention as needed) of one of the most critical portions of the anesthetic-direct laryngoscopy and endotracheal intubation.  A large-bore peripheral IV catheter is also inserted preinduction routinely. Histamine receptor 2 antagonists (H2 blockers) are also indicated in appropriate patients; however, antiemetics like metoclopramide can provoke a hypertensive crisis and are best avoided. Although short-acting alpha 1 antagonists can be administered on the morning of the procedure, longer-acting agents such as phenoxybenzamine and doxazosin are traditionally withheld 12-24 h prior to the operation.  Attention must be paid to the organization of vasoactive infusions to be used intraoperatively. Traditional vasodilator set up includes nitroglycerin, sodium nitroprusside, nicardipine, diltiazem as indicated, esmolol infusion for heart rate control, magnesium sulfate, and vasoconstrictors such as norepinephrine and vasopressin. In patients with the catecholamine cardiomyopathy, inotropes to be added include epinephrine and dobutamine, with milrinone available in the setting of right ventricular dysfunction. For rapid volume expansion, colloids, plasma expanders, and blood products are arranged as indicated. All infusions are connected to tubing that leads to a manifold for central venous administration. In terms of invasive monitoring, central venous cannulation is absolutely indicated for fluid management as well as delivery of vasoactive agents. In addition, pulmonary artery catheters as well as intraoperative transesophageal echocardiography (TEE) probes are placed in appropriate patients. Consideration should be given to the use of rapid transfusion systems for patients with large masses as well as tumors with caval or aortic involvement.
As outlined above, anesthetic induction is one of the most critical portions of the procedure, with every effort being made to limit the hemodynamic stresses of direct laryngoscopy. Agents commonly used include propofol and etomidate. Ketamine is usually avoided due to its sympathomimetic effects, as are ephedrine and meperidine. Of importance, airway instrumentation should only be attempted after obtaining adequate anesthetic depth to avoid tachycardia and hypertension. Propofol has been documented to be safe in these patients; etomidate has the advantage of conferring cardiovascular stability, especially in volume-depleted patients. , All agents that cause histamine release should be avoided. The choice of neuromuscular blocker prior to laryngoscopy is critically important in the pheochromocytoma resection. The depolarizing agent, succinylcholine, has the potential for causing catecholamine surges from the muscle fasciculations that it produces which can mechanically compress the tumor, in addition to stimulation of the autonomic ganglia, both of which can be detrimental.  Pancuronium, a nondepolarizing agent, has a vagolytic effect that can trigger a pressor response in these patients.  Of all the agents used for neuromuscular blockade prior to endotracheal intubation, vecuronium is the most widely used and preferred. It has no autonomic effects, does not cause histamine release, and is the most commonly used paralytic for a pheochromocytoma resection at Mayo Clinic.  Attenuation of the pressor response to laryngoscopy is a crucial aspect of anesthetic induction and adjuncts commonly used include fentanyl in small doses, IV lidocaine, esmolol 0.5 mg/kg bolus, and infusion as indicated, as well as infusions of nitroglycerin, nicardipine, or sodium nitroprusside as needed. Inhaled agents are the mainstay of the anesthetic for a pheochromocytoma resection. In the past few years, enflurane and isoflurane have been extensively used , without complications. Halothane (which is not currently in use in the United States) is contraindicated in pheochromocytoma patients as it is arrhythmogenic, sensitizing the myocardium to circulating catecholamines.  Desflurane, which is favored in ambulatory anesthesia for its low blood-gas partition coefficient (and resultant rapid emergence) does cause significant sympathetic stimulation and is considered by many to be avoided.  Sevoflurane is widely used for pheochromocytoma excision. Given its relatively favorable hemodynamic profile, it is less irritable to the airways than desflurane and lacks arrhythmogenic potential. Nitrous oxide is benign in these patients. Opiate use in the pheochromocytoma resection can vary based on the approach (open vs. laparoscopic), patient opiate tolerance, and hemodynamic issues encountered. Long-acting opiates such as morphine and hydromorphone are routinely used, although some institutions have reported the use of remifentanil successfully. 
| Invasive Monitoring in Pheochromocytoma Resection|| |
Aside from standard American Society of Anesthesiologists monitors, intra-arterial monitoring is the gold standard in the pheochromocytoma resection for beat-to-beat blood pressure monitoring. Central venous catheterization and monitoring is essential in these patients and has been the standard of care for over 50 years.  It allows for monitoring of right atrial pressure and the delivery of vasoactive agents as mentioned earlier. Swan-Ganz catheterization may be indicated in patients with poor left ventricular function from a catecholamine cardiomyopathy, pulmonary hypertension, or significant myocardial disease. Measurement of cardiac output, mixed venous oxygen saturation, as well as pulmonary capillary wedge pressure, may be particularly useful in these higher-risk patients.  The utility of pulmonary artery catheters in these patients may be greater postoperatively following tumor resection for more accurate fluid management in the intensive care unit, particularly in the unstable patient.  Intraoperative TEE has the added advantage of real-time monitoring of intravascular volume status, as well as the earlier detection of myocardial wall motion abnormalities aiding the diagnosis of intraoperative myocardial ischemia. PCC resection can involve significant hemodynamic fluctuations as will be discussed below.
| Intraoperative Hypertension and Hypotension|| |
Hypertension during resection may arise from general sources specific to all operations (positioning, skin incision, intubation) and is usually transient and responds to quick therapy, in these situations, the catecholamine release is from excessive stores in nerve endings.  On the other hand, tumor manipulation usually generates a far more dramatic pressor response that is directly related to significant increases in plasma levels of norepinephrine and epinephrine.  These situations may be associated with severe hemodynamic instability including significant reductions in cardiac output, and associated left ventricular systolic and diastolic dysfunction. Wall motion abnormalities may be noted with intraoperative TEE in the setting of myocardial ischemia. Acute hemodynamic crises during resection are not uncommon and must be immediately treated. The typical hemodynamic crisis in tumor resection may be epinephrine or norepinephrine mediated (depending upon which catecholamine is predominantly secreted by the tumor) and manifests either as severe bradycardia accompanied by hypertension or with severe tachycardia and tachyarrhythmias. Immediate responses should include deepening the depth of anesthesia and rapidly administering direct arterial vasodilators, sodium nitroprusside being the key drug in conjunction with nitroglycerin, to reduce preload. Both drugs have a rapid onset of action and are easily titratable. In resistant cases, nicardipine and/or fenoldopam have been used with success.  The latter being a dopamine (DA-1) agonist causes peripheral vasodilation in conjunction with increasing renal blood flow. In addition, an infusion of an ultrashort-acting beta blocker as an adjunct to control heart rate is extremely effective.  Magnesium sulfate has been increasingly used for hemodynamic control in the pheochromocytoma resection. It is a potent vasodilator inhibiting catecholamine release by directly inhibiting their receptors and is a strong calcium antagonist.  It is used in the operating room (OR) as an IV bolus in the dose of 1-3 g. Multiple data points exist in the pheochromocytoma literature attesting to its benefit in hemodynamic situations like the pheochromocytoma with severe, resistant hypertension. , Being an established antiarrhythmic, it has been used successfully to treat ventricular arrhythmias in pheochromocytoma patients  as well as pediatric patients with these tumors. In addition, pheochromocytoma can be rarely associated with Takotsubo cardiomyopathy,  another condition known to be associated with elevated catecholamine levels. Some have suggested a possible role for magnesium as an important therapeutic agent in these patients.  Communication with the surgeon is critically important before tumor manipulation is begun to reduce the likelihood of major hemodynamic events. Hyperglycemia is common as a result of catecholamine excess, and insulin infusion therapy, as indicated, should be routine management in these patients.
Sudden hypotension may occur following ligation of the tumor. This, in conjunction with a contracted plasma volume, surgical bleeding, and anesthetic-induced vasodilation may cause profound, persistent hypotension. This can, to some extent, be pre-empted by close communication with the surgeon allowing for large-volume fluid bolus administration just prior to tumor ligation. It is not uncommon for the anesthesiologist to administer 2-3 L of fluid (crystalloid and colloid) prior to tumor ligation, in addition to rapidly discontinuing all vasodilators. Data from the British literature  would suggest that massive fluid resuscitation is more effective than vasopressor administration in these situations. Patients who are persistently hypotensive may benefit from intraoperative TEE examination to assess ventricular filling. In terms of vasoactive agents, DA-1, norepinephrine, and vasopressin have been used with success; however, in refractory circulatory shock, acute vasopressin therapy has been increasingly used with documented success. , Because vasopressin does not rely on peripheral adrenergic receptors for its pressor effect, it is particularly effective for refractory hypotension following tumor resection. In addition, once all agents have been in use to little or no effect and fluid therapy has been fully optimized, the use of IV methylene blue may be considered. It has been documented recently for hemodynamic rescue following the pheochromocytoma resection.  Methylene blue is an indicator dye that has been used for treatment of malaria, methemoglobinemia, neonatal hypotension, as well as in the surgical setting to detect urinary tract leaks. , It appears to function through a cyclic guanosine monophosphate inhibition mechanism that plays a key role in vasoplegic syndromes.  It has been reported to have been used in refractory vasoplegic patients with hepatic and renal failure, as well as in the cardiac arena.  Since experience is mostly anecdotal, it cannot be universally recommended in unstable hypotensive patients; however, in doses ranging from 1 to 2 mg/kg it has been used in conditions dominated by profound and pressor-resistant vasoplegia. 
Consideration should also be given to rapid steroid replacement in the hypotensive patient following bilateral adrenalectomies.
| Pheochromocytoma in Uncommon Situations|| |
Emergency surgery in patients with documented PCC or residual PCC from previous operations is not to be taken lightly. Unless it is a true surgical emergency, all patients will need at the very least, assessment of serum and urine catecholamines, complete blood counts and electrolytes, as well as cardiac evaluation with transthoracic echocardiogram as indicated. In the event of a true surgical emergency, complete invasive hemodynamic monitoring is indicated with arterial cannulation, central venous or pulmonary artery cannulation, intraoperative TEE, as well as the availability of appropriate vasodilators such as nitroglycerin, sodium nitroprusside, and nicardipine to immediately treat hypertensive crises as they arise.
Pheochromocytomas in pregnancy is rare, estimated to occur in 1 out of 54,000 pregnancies. , Although rare, when undiagnosed (it can be overlooked given the much higher prevalence of gestational hypertension and preeclampsia), it has a very high maternal and fetal mortality of close to 50%. ,
Laboratory diagnosis is similar to PCC in nonpregnant patients via assessment of fractionated metanephrines (metanephrine and normetanephrine) in blood and urine. In pregnant patients, as per Lenders, PCC can be excluded if the plasma-free metanephrine test is negative.  Preoperative alpha blockade is also the standard of care in this patient population, with the caveat that blood pressure should be maintained to perfuse the uteroplacental circulation. In terms of surgical intervention, most centers employ laparoscopic adrenalectomy, with adrenal cortical-sparing surgery in patients with bilateral disease. In pregnancy, the optimal time for PCC resection is the second trimester - before 24 weeks gestation or after delivery. , In late trimester patients with PCC, Lenders recommends PCC resection simultaneous with C-section or after delivery.
| Immediate Postoperative Management|| |
All pheochromocytoma patients need intensive monitoring postresection, usually in the intensive care unit. Patients who exhibit persistent hemodynamic instability may need postoperative ventilation. Electrolyte and endocrine abnormalities must be ruled out in drowsy and unresponsive patients where hypoglycemia and hyponatremia should be considered high on the differential diagnosis. Appropriate blood glucose and electrolyte monitoring is indicated. Careful attention must be paid to fluid management. In the vast majority of patients who undergo laparoscopic tumor resections, postoperative issues are minimal. Persistent hypotension may indicate surgical bleeding, inadequate fluid resuscitation, or residual anesthetic-induced vasodilatation. In patients who are persistently hypertensive postoperatively, fluid overload, return of autonomic reflexes, inadvertent ligation of the renal artery, or presence of residual tumor should be considered in the differential diagnosis. 
It is important to keep in mind that hypertension may persist in a significant number of patients (50%) following PCC resection, with a tumor recurrence rate of 14% in primary adrenal disease and 30% in extra-adrenal disease. This indicates that long-term follow-up should be considered on all patients following PCC resection. 
| Conclusion|| |
Patients with pheochromocytoma are at significant risk for major adverse cardiac complications in the perioperative period. Successful management requires careful preoperative optimization, meticulous intraoperative planning, and hemodynamic management. All patients need to be monitored vigilantly in the postoperative period given the high-risk of complications as described above.
| References|| |
Golden SH, Robinson KA, Saldanha I, Anton B, Ladenson PW. Clinical review: Prevalence and incidence of endocrine and metabolic disorders in the United States: A comprehensive review. J Clin Endocrinol Metab 2009;94:1853-78.
Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, et al.
Pheochromocytoma and paraganglioma: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2014;99:1915-42.
Myklejord DJ. Undiagnosed pheochromocytoma: The anesthesiologist nightmare. Clin Med Res 2004;2:59-62.
O'Riordan JA. Pheochromocytomas and anesthesia. Int Anesthesiol Clin 1997;35:99-127.
Roizen MF, Horrigan RW, Koike M, Eger IE, 2 nd
, Mulroy MF, Frazer B, et al
. A prospective randomized trial of four anesthetic techniques for resection of pheochromocytoma. Anesthesiology. 1982;57:A43.
Roizen MF, Schreider BD, Hassan SZ. Anesthesia for patients with pheochromocytoma. Anesthesiol Clin North America 1987; 5:269-75.
Iseri LT, Henderson HW, Derr JW. Use of adrenolytic drug, regitine, in pheochromocytoma. Am Heart J 1951;42:129-36.
Mazza A, Armigliato M, Marzola MC, Schiavon L, Montemurro D, Vescovo G, et al.
Anti-hypertensive treatment in pheochromocytoma and paraganglioma: Current management and therapeutic features. Endocrine 2014;45:469-78.
Mihai R, Sadler GP, Bridge H. Adrenergic blockade with phenoxybenzamine and propranolol in a cohort of 60 patients undergoing surgery for phaeochromocytoma. Eur J Anaesthesiol 2008;25:508-10.
Mannelli M. Management and treatment of pheochromocytomas and paragangliomas. Ann N Y Acad Sci 2006;1073:405-16.
Pacak K. Preoperative management of the pheochromocytoma patient. J Clin Endocrinol Metab 2007;92:4069-79.
Lehmann HU, Hochrein H, Witt E, Mies HW. Hemodynamic effects of calcium antagonists. Review. Hypertension 1983;5:II66-73.
Bravo EL. Pheochromocytoma. Curr Ther Endocrinol Metab 1997;6:195-7.
Fishbein L, Orlowski R, Cohen D. Pheochromocytoma/Paraganglioma: Review of perioperative management of blood pressure and update on genetic mutations associated with pheochromocytoma. J Clin Hypertens (Greenwich) 2013; 15:428-34.
Kinney MA, Narr BJ, Warner MA. Perioperative management of pheochromocytoma. J Cardiothorac Vasc Anesth 2002; 16:359-69.
Proye C, Thevenin D, Cecat P, Petillot P, Carnaille B, Verin P, et al.
Exclusive use of calcium channel blockers in preoperative and intraoperative control of pheochromocytomas: Hemodynamics and free catecholamine assays in ten consecutive patients. Surgery 1989;106:1149-54.
Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM. Catecholamine-induced cardiomyopathy. Endocr Pract 2008;14:1137-49.
Mobine HR, Baker AB, Wang L, Wakimoto H, Jacobsen KC, Seidman CE, et al.
Pheochromocytoma-induced cardiomyopathy is modulated by the synergistic effects of cell-secreted factors. Circ Heart Fail 2009;2:121-8.
Osranek M, Bursi F, Gura GM, Young WF Jr, Seward JB. Echocardiographic features of pheochromocytoma of the heart. Am J Cardiol 2003;91:640-3.
Conzo G, Musella M, Corcione F, De Palma M, Ferraro F, Palazzo A, et al.
Laparoscopic adrenalectomy, a safe procedure for pheochromocytoma. A retrospective review of clinical series. Int J Surg 2013;11:152-6.
Kulis T, Knezevic N, Pekez M, Kastelan D, Grkovic M, Kastelan Z. Laparoscopic adrenalectomy: Lessons learned from 306 cases. J Laparoendosc Adv Surg Tech A 2012;22:22-6.
Mellon MJ, Sundaram CP. Laparoscopic adrenalectomy for pheochromocytoma versus other surgical indications. JSLS 2008; 12:380-4.
Nguyen PH, Keller JE, Novitsky YW, Heniford BT, Kercher KW. Laparoscopic approach to adrenalectomy: Review of perioperative outcomes in a single center. Am Surg 2011;77:592-6.
Gumbs AA, Gagner M. Laparoscopic adrenalectomy. Best Pract Res Clin Endocrinol Metab 2006;20:483-99.
Shen WT, Sturgeon C, Clark OH, Duh QY, Kebebew E. Should pheochromocytoma size influence surgical approach? A comparison of 90 malignant and 60 benign pheochromocytomas. Surgery 2004;136:1129-37.
Lee JE, Curley SA, Gagel RF, Evans DB, Hickey RC. Cortical-sparing adrenalectomy for patients with bilateral pheochromocytoma. Surgery 1996;120:1064-70.
Warner MA, vanHeerden JA. Pheochromocytoma: Anesthetic and surgical management employed at the Mayo Clinic. In: Manger WM, Gifford RW Jr, editors. Clinical and Experimental Pheochromocytoma. Cambridge, MA: Blackwell Science; 1996. p. 388-407.
Subramaniam R. Pheochromocytoma - Current concepts in diagnosis and management. Trends Anaesth Crit Care 2011; 1:104-10.
Hull CJ. Phaeochromocytoma. Diagnosis, preoperative preparation and anaesthetic management. Br J Anaesth 1986; 58:1453-68.
Strebel S, Scheidegger D. Propofol-fentanyl anesthesia for pheochromocytoma resection. Acta Anaesthesiol Scand 1991; 35:275-7.
Stoner TR Jr, Urbach KF. Cardiac arrhythmias associated with succinylcholine in a patient with pheochromocytoma. Anesthesiology 1968;29:1228-9.
Jones RM, Hill AB. Severe hypertension associated with pancuronium in a patient with a phaeochromocytoma. Can Anaesth Soc J 1981;28:394-6.
Kinney MA, Warner ME, vanHeerden JA, Horlocker TT, Young WF Jr, Schroeder DR, et al.
Perianesthetic risks and outcomes of pheochromocytoma and paraganglioma resection. Anesth Analg 2000;91:1118-23.
Janeczko GF, Ivankovich AD, Glisson SN, Heyman HJ, El-Etr AA, Albrecht RF. Enflurane anesthesia for surgical removal of pheochromocytoma. Anesth Analg 1977;56:62-7.
Maze M, Smith CM. Identification of receptor mechanism mediating epinephrine-induced arrhythmias during halothane anesthesia in the dog. Anesthesiology 1983;59:322-6.
Lippmann M, Ford M, Lee C, Ginsburg R, Foran W, Raum W, et al.
Use of desflurane during resection of phaeochromocytoma. Br J Anaesth 1994;72:707-9.
Breslin DS, Farling PA, Mirakhur RK. The use of remifentanil in the anaesthetic management of patients undergoing adrenalectomy: A report of three cases. Anaesthesia 2003;58:358-62.
Prys-Roberts C. Phaeochromocytoma - recent progress in its management. Br J Anaesth 2000;85:44-57.
Young JB, Landsberg L. Catecholamines and the adrenal medullain. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, editors. Williams Textbood of Endocrinology. Philadelphia, PA: Saunders; 1998. p. 705-28.
Jovenich JJ. Anesthesia in adrenal surgery. Urol Clin North Am 1989;16:583-7.
Bravo EL, Tarazi RC, Gifford RW, Stewart BH. Circulating and urinary catecholamines in pheochromocytoma. Diagnostic and pathophysiologic implications. N Engl J Med 1979;301:682-6.
Vater M, Achola K, Smith G. Catecholamine responses during anaesthesia for phaeochromocytoma. Br J Anaesth 1983; 55:357-60.
Cooper ZA, Mihm FG. Blood pressure control with fenoldopam during excision of a pheochromocytoma. Anesthesiology 1999;91:558-60.
Zakowski M, Kaufman B, Berguson P, Tissot M, Yarmush L, Turndorf H. Esmolol use during resection of pheochromocytoma: Report of three cases. Anesthesiology 1989;70:875-7.
Houston M. The role of magnesium in hypertension and cardiovascular disease. J Clin Hypertens (Greenwich) 2011;13: 843-7.
Iseri LT, French JH. Magnesium: Nature's physiologic calcium blocker. Am Heart J 1984;108:188-93.
James MF, Cronjé L. Pheochromocytoma crisis: The use of magnesium sulfate. Anesth Analg 2004;99:680-6.
van der Heide K, de Haes A, Wietasch GJ, Wiesfeld AC, Hendriks HG. Torsades de pointes during laparoscopic adrenalectomy of a pheochromocytoma: A case report. J Med Case Rep 2011;5:368.
Agarwal V, Kant G, Hans N, Messerli FH. Takotsubo-like cardiomyopathy in pheochromocytoma. Int J Cardiol 2011;153: 241-8.
Morton AP. Takotsubo cardiomyopathy: A role for magnesium? Heart Rhythm 2010;7:e1.
Desmonts JM, Marty J. Anaesthetic management of patients with phaeochromocytoma. Br J Anaesth 1984;56:781-9.
Roth JV. Use of vasopressin bolus and infusion to treat catecholamine-resistant hypotension during pheochromocytoma resection. Anesthesiology 2007;106:883-4.
Tan SG, Koay CK, Chan ST. The use of vasopressin to treat catecholamine-resistant hypotension after phaeochromocytoma removal. Anaesth Intensive Care 2002;30:477-80.
Amin Nasr A, Fatani J, Kashkari I, Al Shammary M, Amin T. Use of methylene blue in pheochromocytoma resection: Case report. Paediatr Anaesth 2009;19:396-401.
Bosoy D, Axelband J, Pursell RN, Lukaszczyk JJ, Stawicki SP. Utilization of methylene blue in the setting of hypotension associated with concurrent renal and hepatic failure: A concise review. OPUS 12 Sci 2008;2:21-9.
Evora PR, Ribeiro PJ, Vicente WV, Reis CL, Rodrigues AJ, Menardi AC, et al.
Methylene blue for vasoplegic syndrome treatment in heart surgery: Fifteen years of questions, answers, doubts and certainties. Rev Bras Cir Cardiovasc 2009;24:279-88.
Del Duca D, Sheth SS, Clarke AE, Lachapelle KJ, Ergina PL. Use of methylene blue for catecholamine-refractory vasoplegia from protamine and aprotinin. Ann Thorac Surg 2009;87:640-2.
Panos A, Orrit X, Chevalley C, Kalangos A. Dramatic post-cardiotomy outcome, due to severe anaphylactic reaction to protamine. Eur J Cardiothorac Surg 2003;24:325-7.
Viaro F, Dalio MB, Evora PR. Catastrophic cardiovascular adverse reactions to protamine are nitric oxide/cyclic guanosine monophosphate dependent and endothelium mediated: Should methylene blue be the treatment of choice? Chest 2002; 122:1061-6.
Harrington JL, Farley DR, van Heerden JA, Ramin KD. Adrenal tumors and pregnancy. World J Surg 1999;23:182-6.
Sarathi V, Lila AR, Bandgar TR, Menon PS, Shah NS. Pheochromocytoma and pregnancy: A rare but dangerous combination. Endocr Pract 2010;16:300-9.
Schenker JG, Chowers I. Pheochromocytoma and pregnancy. Review of 89 cases. Obstet Gynecol Surv 1971;26:739-47.
Schenker JG, Granat M. Phaeochromocytoma and pregnancy: An updated appraisal. Aust N Z J Obstet Gynaecol 1982;22:1-10.
Lenders JW. Pheochromocytoma and pregnancy: A deceptive connection. Eur J Endocrinol 2012;166:143-50.
Ahlawat SK, Jain S, Kumari S, Varma S, Sharma BK. Pheochromocytoma associated with pregnancy: Case report and review of the literature. Obstet Gynecol Surv 1999;54:728-37.
Mannelli M, Bemporad D. Diagnosis and management of pheochromocytoma during pregnancy. J Endocrinol Invest 2002;25:567-71.
Plouin PF, Chatellier G, Fofol I, Corvol P. Tumor recurrence and hypertension persistence after successful pheochromocytoma operation. Hypertension 1997;29:1133-9.
Amar L, Servais A, Gimenez-Roqueplo AP, Zinzindohoue F, Chatellier G, Plouin PF. Year of diagnosis, features at presentation, and risk of recurrence in patients with pheochromocytoma or secreting paraganglioma. J Clin Endocrinol Metab 2005;90:2110-6.
|This article has been cited by|
||Paraganglioma Presenting as Hypoxia and Syncope in Pregnancy: A Case Report
| ||Emad A. Elsamadicy,Shekoufeh Yazdani,Arunthevaraja Karuppiah,Isabel Marcano,Ozhan Turan,Bhavani Shankar Kodali,Rebecca Jessel |
| ||A&A Practice. 2021; 15(3): e01411 |
|[Pubmed] | [DOI]|
||Anesthesia for Endocrine Emergencies
| ||Dasun Peramunage,Sara Nikravan |
| ||Anesthesiology Clinics. 2020; |
|[Pubmed] | [DOI]|
||Anesthesia Case of the Month
| ||Kristina Feigin,E. Hathaway Fiocchi,Meghan A. Fleming,Andrea L. Looney |
| ||Journal of the American Veterinary Medical Association. 2020; 257(11): 1125 |
|[Pubmed] | [DOI]|
||Retrospective evaluation of labetalol as antihypertensive agent in dogs
| ||Francesco Zublena,Chiara De Gennaro,Federico Corletto |
| ||BMC Veterinary Research. 2020; 16(1) |
|[Pubmed] | [DOI]|
||Approach to the Patient: Perioperative Management of the Patient with Pheochromocytoma or Sympathetic Paraganglioma
| ||Annika M A Berends,Michiel N Kerstens,Jacques W M Lenders,Henri J L M Timmers |
| ||The Journal of Clinical Endocrinology & Metabolism. 2020; 105(9) |
|[Pubmed] | [DOI]|
||Phenoxybenzamine Is Unlikely to Be the Intraoperative Antihypertensive of Choice in Pheochromocytoma
| ||Hilary P. Grocott |
| ||The Annals of Thoracic Surgery. 2019; 107(2): 688 |
|[Pubmed] | [DOI]|
||Clinical features, anaesthetic management and perioperative complications seen in three horses with pheochromocytoma
| ||Daisy Jessica Norgate,Andrew Foster,Bettina Dunkel,Simon Spiro,Kata Veres-Nyeki |
| ||Veterinary Record Case Reports. 2019; 7(1): e000744 |
|[Pubmed] | [DOI]|
||Ectopic pheochromocytoma or paraganglioma of the ZUCKERKANDL organ: A case report and review of the literature
| ||Nayi Zongo,Adjirata Koama,Benilde Marie Ange Kambou/Tiemtoré,Nina A. Nde/Ouédraogo,Maurice Zida,Marie N.L. Ouédraogo,Edgard Ouangré,Adama Sanou,Olga Melanie Lompo,Ousséni Diallo,Claudine Lougué/Sorgho,Rabiou Cissé |
| ||International Journal of Surgery Case Reports. 2019; 60: 120 |
|[Pubmed] | [DOI]|
||Postoperative Management in Patients with Pheochromocytoma and Paraganglioma
| ||Divya Mamilla,Katherine Araque,Alessandra Brofferio,Melissa Gonzales,James Sullivan,Naris Nilubol,Karel Pacak |
| ||Cancers. 2019; 11(7): 936 |
|[Pubmed] | [DOI]|
||Anaesthetic management of a phaeochromocytoma excision in a dog
| ||Chris Miller,Pat Pawson |
| ||Veterinary Record Case Reports. 2019; 7(4): e000931 |
|[Pubmed] | [DOI]|
||Hypertensive crisis of a patient with undiagnosed paraganglioma
| ||Kyu Bum Cho,Jeong Seok Lee,Jung Ha Lee,Dae Hun Yun,Cheon Hee Park |
| ||Medical Biological Science and Engineering. 2019; 2(2): 64 |
|[Pubmed] | [DOI]|
||The Duration of Preoperative Administration of Single a-Receptor Blocker Phenoxybenzamine before Adrenalectomy for Pheochromocytoma: 18 Years of Clinical Experience from Nationwide High-Volume Center
| ||Jie Tian,Zhengqing Bao,Yiming Yuan,Dong Fang,Yonghao Zhan,Tianyu Wang,Zheng Zhang,Zhou Liqun |
| ||BioMed Research International. 2019; 2019: 1 |
|[Pubmed] | [DOI]|
||Echocardiographic Guidance for Surgical Excision of the Intracardiac Component of a Pheochromocytoma
| ||Dinesh J. Kurian,Angela X. Li,Srikar Rao,Agathoklis Konstantinidis,Sanziana A. Roman,Miklos D. Kertai |
| ||Seminars in Cardiothoracic and Vascular Anesthesia. 2018; 22(3): 324 |
|[Pubmed] | [DOI]|
||MANAGEMENT OF PHEOCHROMOCYTOMA IN THE SETTING OF ACUTE STROKE
| ||Solomon Oak,Mahsa Javid,Glenda G. Callender,Tobias Carling,Courtney E. Gibson |
| ||AACE Clinical Case Reports. 2018; 4(3): e245 |
|[Pubmed] | [DOI]|
||ANAESTHESIA FOR LAPAROSCOPIC EXCISION OF PHEOCHROMOCYTOMA AND PARAGANGLIOMAS IN PAEDIATRIC POPULATION- OUR INSTITUTIONAL EXPERIENCE
| ||Kunigal Ravishankar Chandrakala,Dammaningala Venkataramaiah Bhagya,Yabagodu Ramayya Chandrika |
| ||Journal of Evolution of Medical and Dental Sciences. 2017; 6(93): 6770 |
|[Pubmed] | [DOI]|
||Perioperative Management of Pheochromocytoma
| ||Julian Naranjo,Sarah Dodd,Yvette N. Martin |
| ||Journal of Cardiothoracic and Vascular Anesthesia. 2017; |
|[Pubmed] | [DOI]|
||ANAESTHETIC MANAGEMENT OF A PAEDIATRIC SUPRARENAL PHEOCHROMOCYTOMA
| ||Naveen Kundilmadom Vijayan,Niti Dalal,Aastha Gaba |
| ||Journal of Evidence Based Medicine and Healthcare. 2017; 4(79): 4693 |
|[Pubmed] | [DOI]|
||Anesthetic Management of Clinically Silent Familial Pheochromocytoma with MEN 2A: A Report of Four Cases
| ||Shipra Aggarwal,Vandana Talwar,Pooja Virmani,Suniti Kale |
| ||Indian Journal of Surgery. 2016; |
|[Pubmed] | [DOI]|
||Perioperative Management of Adrenalectomy and Inferior Vena Cava Reconstruction in a Patient With a Large, Malignant Pheochromocytoma With Vena Caval Extension
| ||Stephen H. Gregory,Suraj M. Yalamuri,Sharon L. McCartney,Syed A. Shah,Julie A. Sosa,Sanziana Roman,Brian J. Colin,Claude Lentschener,Ray Munroe,Saumil Patel,Jared W. Feinman,John G.T. Augoustides |
| ||Journal of Cardiothoracic and Vascular Anesthesia. 2016; |
|[Pubmed] | [DOI]|
||Expanding the horizon of robotic surgery to large pelvic paraganglioma
| ||Santosh Kumar,M. Pragatheeswarane,Aditya Prakash Sharma,Kshitij Bishnoi,Manjeet Kumar Sharma,Vikas Kumar Panwar,Sameer Sethi |
| ||Journal of Robotic Surgery. 2016; |
|[Pubmed] | [DOI]|