|LETTER TO EDITOR
|Year : 2020 | Volume
| Issue : 1 | Page : 127-128
Laparoscopic cholecystectomy in a patient with distal renal tubular acidosis associated with Sjogren's syndrome: An anesthetic challenge
Snigdha Bellapukonda, Kiran Jangra, Pranshuta Sabharwal
Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh, India
|Date of Submission||22-Mar-2019|
|Date of Acceptance||24-May-2019|
|Date of Web Publication||18-Feb-2020|
Dr. Kiran Jangra
Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh - 160 012
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Bellapukonda S, Jangra K, Sabharwal P. Laparoscopic cholecystectomy in a patient with distal renal tubular acidosis associated with Sjogren's syndrome: An anesthetic challenge. J Anaesthesiol Clin Pharmacol 2020;36:127-8
|How to cite this URL:|
Bellapukonda S, Jangra K, Sabharwal P. Laparoscopic cholecystectomy in a patient with distal renal tubular acidosis associated with Sjogren's syndrome: An anesthetic challenge. J Anaesthesiol Clin Pharmacol [serial online] 2020 [cited 2021 Jan 27];36:127-8. Available from: https://www.joacp.org/text.asp?2020/36/1/127/278476
Distal renal tubular acidosis (Distal-RTA) is a condition of chronic metabolic acidosis. Creation of pneumoperitoneum in these patients aggravates acidosis by increasing the Pa CO2 in blood gases. Hence, we report here a rare combination of pneumoperitoneum in a patient with partially compensated distal-RTA.
We describe here the case of a 26 Y/F (Wt-55 kg, Ht-148 cm) with cholelithiasis having a past history of two episodes of quadriplegia 4 years back (6 months apart) secondary to hypokalemia. During both the episodes, she was managed medically and fully recovered. She was diagnosed to have type-1 RTA following the diagnostic workup for hypokalemia. She satisfied the “Sjögren's International Collaborative Clinical Alliance” (SICCA) criteria for Sjogren's syndrome. She was being treated with tablet sodium bicarbonate, tablet hydroxychloroquine, potassium chloride syrup, and tablet pilocarpine. Her serum potassium level was well maintained >3 mEq/L and she was completely asymptomatic. Currently, she presented with symptomatic gallstone disease and was posted for laparoscopic cholecystectomy. Preoperative blood investigations, chest X-ray, and electrocardiogram were within normal limits. All drugs were continued.
On the day of surgery, preoperative arterial blood gas (ABG) analysis showed; pH-7.42, PaCO2- 26.7 mmHg, PaO2-93.8 mm Hg, HCO3—-15.4 mmol/L, BE-7.7, SpO2- 99%, Na+-134.8 mEq/L, K+-3.17 mEq/L, ionized Ca2+-1.06 mmol/L, and Lactate- 2.01 mmol/L. As the pH was compensated to normal, we proceeded with elective surgery. In the operation theater, standard ASA monitors were attached. The patient was induced with injection morphine 7.5 mg and injection propofol 1–2 mg/kg (titrated to loss of verbal response), and injection atracurium 30 mg was used to facilitate tracheal intubation. Anesthesia was maintained with propofol infusion @ 50–70 mcg/kg/min and O2: N2O (40%) mixture. Ventilation was adjusted to maintain end-tidal carbon-di-oxide (EtCO2) to 26 to 27 mmHg. Warming blankets and warm fluids were used to prevent hypothermia, and a total of 700 ml Ringer's lactate solution was used intraoperatively. The surgery lasted for 70 min and was uneventful. ABG before extubation showed; pH-7.4, PaCO2-28.2 mmHg, PaO2-212.1 mmHg, HCO3- 15.4 mEq/L, BE- -6.9 mmol/L, SpO2- 98.7%, Na+-135.2 mEq/L, K+- 3.51 mEq/L, ionized Ca2+-1.09 mmol/L, Lactate-2.01 mmol/L, and Hct-36. At the end of surgery, neuromuscular blockade was reversed using neostigmine 2.5 mg, and glycopyrrolate 0.5 mg and trachea was extubated successfully without any residual muscle weakness.
To maintain blood pH, acid-base homeostasis involves the balance of carbonic acid (H2 CO3), bicarbonate ion (HCO3−), and carbon dioxide (CO2). CO2 reacts with water (H2O) to form (H2 CO3), which rapidly dissociates to form HCO3− and a hydrogen ion (H+) as shown in the following equation, H2O + CO2⟺H2 CO3⟺H++ HCO3-. This reaction is catalyzed by carbonic anhydrase enzyme.
In distal RTA, there is increased luminal membrane permeability to H+. Impaired H+ ion secretion results in the shift of balance toward left resulting in decreased intracellular HCO3− and metabolic acidosis (normal anion gap acidosis). To maintain electrical neutrality, K+ secretion is proportionately increased. Hypokalemia (<2 mEq/L) potentiates the neuromuscular blockade, causes muscle paralysis, respiratory arrest, and arrhythmias.,, The respiratory system compensates for low pH by hyperventilation that decreases the pressure of arterial CO2. Distal RTA is mostly caused by autoimmune disorders such as Sjogren's syndrome and rheumatoid arthritis., High autoantibody titers in Sjogren's are directed against carbonic anhydrase type II, which can impair the intracellular production of H+ and hence its secretion.
The primary goal of the anesthesiologist in the case of chronic metabolic acidosis is to maintain the intraoperative acid-base balance to ensure early extubation. Patients with RTA have a chronically low pH with low bicarbonate ions and low partial pressure of arterial CO2(PaCO2). Laparoscopic surgeries become a challenge here as there is an increase in PaCO2 that aggravates the acidosis. Acute acidosis leads to the shift of potassium from the intracellular compartment to the intravascular compartment, which may result in alarming hyperkalemia in a well-optimized patient.
Hence, ventilation should be titrated to maintain PaCO2 around the pre-induction baseline values. Rapid correction of chronic metabolic acidosis is not advised intraoperatively during surgery as it can take away respiratory drive. Intraoperative hypothermia also aggravates acidosis by compromising peripheral circulation and should be avoided. Serum K+ levels should be monitored to avoid both hypo and hyperkalemia. Non-steroidal anti-inflammatory drugs should be avoided as they may aggravate distal RTA. The dosage of long-acting opioids should be titrated closely as excessive sedation also increases PaCO2.
Proper precautions to avoid hypothermia, strict vigilance with regard to ventilator settings avoiding both hypo and hyperventilation, maintenance of serum potassium levels, avoiding isotonic saline (prevent hyperchloremic metabolic acidosis), and avoiding the use of nephrotoxic drugs is the key for successful intraoperative management of a patient with distal RTA for laparoscopic surgeries.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
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Conflicts of interest
There are no conflicts of interest.
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