Users Online: 606 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  
Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 

RSACP wishes to inform that it shall be discontinuing the dispatch of print copy of JOACP to it's Life members. The print copy of JOACP will be posted only to those life members who send us a written confirmation for continuation of print copy.
Kindly email your affirmation for print copies to [email protected] preferably by 30th June 2019.


Table of Contents
Year : 2020  |  Volume : 36  |  Issue : 2  |  Page : 272-273

Evolving spectrum of dexmedetomidine preconditioning for Ischemia–reperfusion injury amelioration

Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, India

Date of Submission02-Dec-2019
Date of Acceptance26-Dec-2019
Date of Web Publication15-Jun-2020

Correspondence Address:
Dr. Rohan Magoon
Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi - 110 001
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joacp.JOACP_408_19

Rights and Permissions

How to cite this article:
Kohli JK, Magoon R, Dey S, Kashav R. Evolving spectrum of dexmedetomidine preconditioning for Ischemia–reperfusion injury amelioration. J Anaesthesiol Clin Pharmacol 2020;36:272-3

How to cite this URL:
Kohli JK, Magoon R, Dey S, Kashav R. Evolving spectrum of dexmedetomidine preconditioning for Ischemia–reperfusion injury amelioration. J Anaesthesiol Clin Pharmacol [serial online] 2020 [cited 2020 Oct 26];36:272-3. Available from:


Ischemia–reperfusion injury (IRI) is inexorably linked to a wide gamut of clinical settings such as myocardial revascularization, organ transplantation, vascular procedures, gastrointestinal surgeries, and intraoperative tourniquet application. The restoration of perfusion to ischemic tissues is characterized by microvascular dysfunction, endothelial cell activation, generation of oxygen free radicals, and leukocyte adhesion. This complex inflammatory milieu predisposes to organ dysfunction which accounts for an elevated morbidity and mortality. Therefore, diverse techniques such as ischemic preconditioning, remote ischemia preconditioning, ischemic postconditioning, and pharmacological preconditioning have been evaluated for the attenuation of IRI.

In this context, many anesthetic medications (inhalational agents, propofol, ketamine, etc.) have been evaluated for pharmacological preconditioning.[1] Interestingly, a considerable degree of evidence regarding the role of dexmedetomidine in IRI amelioration has emanated from the animal studies over the last decade.[1] These laboratory studies have demonstrated a promising potential of dexmedetomidine in reducing the inflammatory and oxidative stress in major organs.

The aforementioned fact has motivated the recent emphasis on a formal evaluation of the impact of dexmedetomidine on IRI across diverse predisposed clinical settings. Initial few studies have revealed that dexmedetomidine infusion markedly reduces the ischemia–reperfusion markers (hypoxanthine and malondialdehyde, respectively) associated with tourniquet application.[2] Another study by Kundra et al. in patients undergoing aortobifemoral bypass procedure demonstrated an attenuated skeletal muscle IRI as suggested by lower postprocedural creatine phosphokinase levels.[3] Chi et al. outlined reduced postoperative cardiac troponin I and creatine kinase MB following the administration of dexmedetomidine in off-pump coronary artery bypass grafting.[4] Recent clinical studies characterized a hepatic protective effect attributable to dexmedetomidine in living donors and in subjects undergoing hepatectomy.[1],[5]

A number of caveats surface on a meticulous evaluation of the literature regarding the role of dexmedetomidine in IRI amelioration. First and foremost, the timing of drug administration is closely related to the subsequent impact on IRI, with most of the researchers depicting a beneficial impact only with an initiation prior to ischemia.[1] The literature elucidates that dexmedetomidine induces subtle alterations in signaling pathways, membrane receptors, mediators, and transmitters which formulate the putative mechanisms of protection. Second, albeit the demonstration of a dose-dependent attenuation of IRI, the optimal dosage regimen continues to be investigated in order to closely balance the efficacy and safety profile. Third, there is a definitive lack of human trials over a range of many other predisposed perioperative scenarios evaluating reperfusion lung injury. Similarly, renal IRI, particularly in diabetic and hypertensive cohort, merits further evaluation.

To conclude, the era of translational research continues to unveil a number of novel discoveries. However, it is certainly the right time to move to more human trials evaluating the role of dexmedetomidine in ameliorating IRI aimed at ensuring favorable perioperative outcomes, particularly pertinent in the clinical setting of organ transplantation and revascularization.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Zhang Y, Liu M, Yang Y, Cao J, Mi W. Dexmedetomidine exerts a protective effect on ischemia-reperfusion injury after hepatectomy: A prospective, randomized, controlled study. J Clin Anesth 2019:109631. doi: 10.1016/j.jclinane. 2019.109631. [Epub ahead of print].  Back to cited text no. 1
Yagmurdur H, Ozcan N, Dokumaci F, Kilinc K, Yilmaz F, Basar H. Dexmedetomidine reduces the ischemia–reperfusion injury markers during upper extremity surgery with tourniquet. J Hand Surg Am 2008;33:941-7.  Back to cited text no. 2
Kundra TS, Thimmarayappa A, Dhananjaya M, Manjunatha N. Dexmedetomidine for prevention of skeletal muscle ischemia-reperfusion injury in patients undergoing aortobifemoral bypass surgery in patients of chronic limb ischemia: A prospective double-blind randomized controlled study. Ann Card Anaesth 2018;21:22-5.  Back to cited text no. 3
[PUBMED]  [Full text]  
Chi X, Liao M, Chen X, Zhao Y, Yang L, Luo A, et al. Dexmedetomidine attenuates myocardial injury in off-pump coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth 2016;30:44-50.  Back to cited text no. 4
Fayed NA, Sayed EI, Saleh SM, Ehsan NA, Elfert AY. Effect of dexmedetomidine on hepatic ischemia-reperfusion injury in the setting of adult living donor liver transplantation. Clin Transplant 2016;30:470-82.  Back to cited text no. 5


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded123    
    Comments [Add]    

Recommend this journal