Users Online: 1030 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  
Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 

RSACP wishes to inform that it shall be discontinuing the dispatch of print copy of JOACP to it's Life members. The print copy of JOACP will be posted only to those life members who send us a written confirmation for continuation of print copy.
Kindly email your affirmation for print copies to [email protected] preferably by 30th June 2019.


Table of Contents
Year : 2020  |  Volume : 36  |  Issue : 2  |  Page : 279-280

Undiagnosed hypothyroidism with delayed recovery: A case report

Department of Anesthesiology and Critical Care, UCMS and GTB Hospital, Delhi, India

Date of Submission19-Mar-2018
Date of Acceptance26-Jun-2019
Date of Web Publication15-Jun-2020

Correspondence Address:
Dr. Shilpa Agarwal
Department of Anesthesiology and Critical Care, UCMS and GTB Hospital, Delhi - 110 095
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joacp.JOACP_85_18

Rights and Permissions

How to cite this article:
Agarwal S, Banerjee A, Jain N. Undiagnosed hypothyroidism with delayed recovery: A case report. J Anaesthesiol Clin Pharmacol 2020;36:279-80

How to cite this URL:
Agarwal S, Banerjee A, Jain N. Undiagnosed hypothyroidism with delayed recovery: A case report. J Anaesthesiol Clin Pharmacol [serial online] 2020 [cited 2020 Dec 2];36:279-80. Available from:


We report a case of delayed recovery from general anesthesia, which was later on diagnosed as a case of hypothyroidism.

A 60-year female patient was posted for elective open cholecystectomy with heart rate 47/min, blood pressure 140/80 mmHg, and normal electrocardiograph. Patient had no other comorbidities and was not any drugs. Her echocardiography revealed stage I left ventricular diastolic dysfunction with normal systolic functions. Medicine referral was done for bradycardia. On operating table (OT) table, her heart rate (HR) increased to 58/min after injecting atropine 0.6 mg intravenously (IV). Anesthesia was induced with intravenous morphine, thiopentone, and vecuronium with endotracheal intubation and maintained with isoflurane, nitrous oxide, and oxygen uneventfully. At the end, patient recovered well with adequate spontaneous respiration and neuromuscular blockade was reversed with injection neostigmine and glycopyrrolate. However, following extubation, patient became drowsy and apneic. Trachea was reintubated and intermittent positive pressure ventilation was restarted. Fresh reports revealed normal electrolytes and blood gas analysis. Patient was re-evaluated clinically and was observed to have very thick and rough skin (probably missed in preanesthetic evaluation), low body temperature, and bradycardia without thyroid swelling.

Suspecting hypothyroidism, blood sample was sent for TSH estimation after 2.5 h of reintubation; and as injectable thyroxine was not available, two tablets of Thyroxin 100 μg each were given through Ryle's tube empirically on emergency basis. Patient recovered well after 4 h of elective postoperative ventilation. She became conscious with adequate spontaneous ventilation. Trachea was extubated. After surgery, corticosteroid replacement therapy was started as 100 mg three times a day and continued as oral therapy, since hypothyroidism is commonly associated with adrenal insufficiency.

Her diagnosis was later confirmed as hypothyroidism after receiving reports of TSH level (TSH: 111 μIU/L). She was put on tablet Eltroxin 100 μg daily thereafter.

Hypothyroidism may be present in subclinical form. The anesthetic requirement of hypothyroid patients has not been analyzed so far in any study; but clinically, they are found to be more sensitive to anesthetic drugs and sedatives affecting anesthetic management.[1],[2] Clinical signs of hypothyroidism may range from cold intolerance to constipation, depression, lethargy, muscle weakness, slow movement, dry skin, slow gastric emptying, sleep apnea, depression of ventilatory response to hypoxia, and hypercarbia.[3] The normal range of TSH is 0.3–4.5 mU/L. Primary hypothyroidism is diagnosed through detection of a low free T4 and a high TSH level. A rising TSH level is the most sensitive indicator of failing thyroid function.[4]

Hypothyroidism causes increased responsiveness to central nervous system depressants and neuromuscular blocking agents. Increased sensitivity may be secondary to reduced cardiac output and blood volume, abnormal baroreceptor function, slowing of drug metabolism, and excretion. Decreased neuromuscular excitability, decreased ventilatory response to hypoxia, and hypercarbia are enhanced by anesthetic agents.[1],[4] Due to depression of vascular and respiratory reflexes, hypotension, cardiac arrest and delayed recovery of spontaneous ventilation is common in hypothyroid patients.[5] Such patients should be rendered euthyroid before the surgery. Regional anesthesia should be preferred, if the surgery cannot be delayed.[5]

To conclude, a patient of persistent bradycardia may have other than cardiac cause. In cases of emergency, signs of hypothyroidism may be managed empirically with enteral thyroid hormone replacement state, if parenteral form of thyroxine is not available.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that her name and initials will not be published and due efforts will be made to conceal her identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Wall RT. Endocrine disease. In: Hines RL, Marschall KE, editors. Stoelting's Anesthesia and Co-Existing Disease. 6th ed. Philadelphia: Elsevier Saunders; 2012. p. 386-91.  Back to cited text no. 1
Weinberg AD, Brennan MD, Gorman CA, Marsh HM, O'Fallon WM. Outcome of anesthesia and surgery in hypothyroid patients. Arch Inter Med 1983;143:893-7.  Back to cited text no. 2
Bostan H, Kazdal H, Tomak Y. Hypothyroidism: A rare cause of delayed postoperatıve recovery. Internet J Anesthesiol 2010;29:1-4.  Back to cited text no. 3
Miller RD, Cohen NH, Eriksson LI. Anesthetic implications of concurrent diseases. In: Miller RD, Cohen NH, Eriksson LI, editors. Millers Anesthesia. 7th ed. Philadelphia: Elsevier; 2010. p. 1170.  Back to cited text no. 4
Connery LE, Coursin DB. Assessment and therapy of selected endocrine disorders. Anesthesiol Clin North Am 2004;22:93-123.  Back to cited text no. 5


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded77    
    Comments [Add]    

Recommend this journal