Journal of Anaesthesiology Clinical Pharmacology

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 31  |  Issue : 3  |  Page : 339--343

Effect of a single bolus of dexamethasone on intraoperative and postoperative pain in unilateral inguinal hernia surgery


Muhammad Vaiz Asad, Fauzia Anis Khan 
 Department of Anaesthesiology, Aga Khan University, Karachi, Pakistan

Correspondence Address:
Fauzia Anis Khan
Department of Anaesthesiology, Aga Khan University, P.O. Box 3500, Stadium Road, Karachi - 74800
Pakistan

Background and Aims: Opioids are commonly used to provide perioperative analgesia, but have many side-effects. Addition of co-analgesics results in reducing the dosage and hence the side-effects of opioids. The objective of this study was to compare the analgesic efficacy of fentanyl (1 micro/kg−1) administered alone, with fentanyl (0.75 micro/kg−1) and dexamethasone (8 mg) combination, in patients undergoing day care unilateral inguinal hernia repair. Material and Methods: Patients scheduled for the day care unilateral inguinal hernia repair were randomized to receive either saline and fentanyl 1 micro/kg−1 (control group) or 8 mg dexamethasone with fentanyl 0.75 micro/kg−1 (study group) immediately before induction of anesthesia in a double-blind clinical trial. Anesthesia technique and rescue analgesia regimen were standardized. Intraoperatively, pain was assessed based on hemodynamic variability and postoperatively by visual analog scale. Results: The mean heart rate, systolic and the diastolic blood pressure at 1, 5, 20 and at 30 min after incision, were significantly higher in the control group (P ≤ 0.001) when compared to the study group. Intra-operative rescue analgesia was required in 32 (100%) and 19 (59.4%) patients in control group and study group respectively (P = 0.0002). Mean pain scores measured at fixed time periods postoperatively were significantly higher in the control group when compared to study group (P ≤ 0.001). Postoperative rescue analgesia was needed in 32 (100%) versus 24 (75%) patients in the control group and study group respectively, but this difference was not statistically significant (P = 0.285). Conclusion: We conclude that the addition of 8 mg of preoperative intravenous dexamethasone to 0.75 micro/kg−1 fentanyl was effective in reducing intraoperative and postoperative pain in the 1 st h after unilateral inguinal hernia surgery.


How to cite this article:
Asad MV, Khan FA. Effect of a single bolus of dexamethasone on intraoperative and postoperative pain in unilateral inguinal hernia surgery.J Anaesthesiol Clin Pharmacol 2015;31:339-343


How to cite this URL:
Asad MV, Khan FA. Effect of a single bolus of dexamethasone on intraoperative and postoperative pain in unilateral inguinal hernia surgery. J Anaesthesiol Clin Pharmacol [serial online] 2015 [cited 2021 Apr 12 ];31:339-343
Available from: https://www.joacp.org/article.asp?issn=0970-9185;year=2015;volume=31;issue=3;spage=339;epage=343;aulast=Asad;type=0